The Impact of Growth Hormone in Obese Cases With Covid-19
试验速览
- 阶段
- 4 期
- 状态
- 撤回
- 发起方
- 试验地点
- 1
- 主要终点
- Need for hospitalization
研究概览
简要总结
The use of growth hormone in obese cases with COVID-19 may help them to recover earlier.
详细描述
It is well known that lymphoid organs such the thymus, the spleen and peripheral blood produce growth hormone (GH) and GH receptor is expressed on different subpopulations of lymphocytes. Many in vitro and in animal studies demonstrate an important role of GH in immunoregulation. GH stimulates T and B cells proliferation and immunoglobulin synthesis, enhances the maturation of myeloid progenitor cells and is also able to modulate cytokine response.
The use of growth hormone in obese cases with COVID-19 may help them to recover earlier.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Obese with BMI > 30
排除标准
- •History of hypersensitivity to GH
研究组 & 干预措施
Growth hormone
Recombinant GH will be used for those patients
干预措施: Growth Hormone (Drug)
Placebo
Saline will be used
干预措施: Placebo (Drug)
结局指标
主要结局
Need for hospitalization
时间窗: one to two weeks
need to be hospitalized due to deterioration
次要结局
- Time to recovery(one to four weeks)
- Percentage of reduction in CRP(one to two weeks)
- Percentage of reduction in Ferritin(one to two weeks)
- Time to recovery from leucopenia(one to two weeks)
- Percentage of reduction in LDH(one to two weeks)