NCT07008274已完成不适用
Laparoscopic Sleeve Gastrectomy-Induced Decline in Plasma Asprosin and Its Association With Metabolic Recovery
Northern Jiangsu People's Hospital1 个研究点 分布在 1 个国家目标入组 85 人开始时间: 2021年1月1日最近更新:
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 85
- 试验地点
- 1
- 主要终点
- Plasma asprosin levels at 3, 6, and 12 months
研究概览
简要总结
the present study aimed to systematically assess the changes in plasma asprosin levels at 3, 6, and 12 months after LSG, to explore the relationships between asprosin dynamics and key metabolic parameters, including body mass index (BMI), fasting glucose, insulin resistance assessed by the homeostasis model (HOMA-IR), and lipid profiles, and to compare asprosin concentrations between bariatric patients and healthy normal-weight controls.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Crossover
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •age between 18 and 65 years;
- •body mass index (BMI) ≥37.5 kg/m², or BMI ≥32.5 kg/m² with at least one obesity-related comorbidity;
- •availability of complete clinical data and stored plasma samples at preoperative baseline and at 3, 6, and 12 months postoperatively.
排除标准
- •history of prior bariatric or gastrointestinal surgery;
- •active malignancy, chronic inflammatory or infectious disease, or severe hepatic or renal dysfunction;
- •pregnancy during the study period;
- •incomplete clinical or biochemical data.
结局指标
主要结局
Plasma asprosin levels at 3, 6, and 12 months
时间窗: 1 year
次要结局
- BMI at 3, 6, and 12 months(1 year)
研究者
Daorong Wang
Director
Northern Jiangsu People's Hospital
研究点 (1)
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