Metabolic Availability of Lysine From Rice
- Conditions
- Healthy Adults
- Registration Number
- NCT01474226
- Lead Sponsor
- The Hospital for Sick Children
- Brief Summary
The purpose of this study is to investigate the digestibility of the amino acid lysine in cooked rice in adult men using stable isotope technique.
- Detailed Description
The investigators objective is to determine the metabolic availability (MA) of lysine in cooked white rice protein using the indicator amino acid oxidation (IAAO) technique. Five men will receive graded levels (20, 40, and 60, and 70%) of the lysine requirement of 35 mg/kg/d as a crystalline AA mixture,and cooked rice protein (20, 40 and 60%), respectively.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 5
- Healthy Adult males (18 to 50years old)
- A history of recent weight loss or illness
- Use of any medication at the time of entry into the study.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method Metabolic Availability of lysine 45 min after intake of the fourth hourly meal (before tracer infusion)) 3 breath samples will be taken to provide a baseline F13CO2 measurement (Level of phenylalanine oxidation). Breath samples will be collected and analyzed for 13CO2 enrichment.
- Secondary Outcome Measures
Name Time Method Metabolic Availability of Lysine Post Tracer Infusion (between 150 and 240 min of tracer infusion) 4 breath samples will be taken to provide F13CO2 measurement (Level of phenylalanine oxidation).Breath samples will be collected and analyzed for 13CO2 enrichment.
Trial Locations
- Locations (1)
The Hospital for Sick Children
🇨🇦Toronto, Ontario, Canada
The Hospital for Sick Children🇨🇦Toronto, Ontario, Canada