GLUCOSAMINE/CHONDROITIN and PHYSICAL THERAPY EFFECTS ON OLDER POPULATION WITH KNEE OSTEOARTHRITIS

Not Applicable

Completed

• Conditions: Knee Osteoarthritis
• Interventions: Combination Product: glucosamine chondritin & Physiotherapy; Other: Glucosamine Chondroitin

• Registration Number: NCT05321836
• Lead Sponsor: Muhammad salman, PT

Brief Summary

to see the effect of glucosamine chondratin sulfate with and without physiotherapy in knee osteoarthritis

Detailed Description

it is a randomized control trail to evaluate the effectiveness of glucosamine chondratin sulfate alone and in combination with physiotherapy on knee osteoarthritis

Study Timeline

• Study Start: 2021-07-26
• Primary Completion: 2022-03-25
• Study Completion: 2022-03-25
• Study First Submitted: 2022-03-26
• Status Verified: 2022-04
• Study First Submitted QC: 2022-04-04
• Last Update Submitted: 2022-04-04
• Study First Posted: 2022-04-11
• Last Update Posted: 2022-04-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• age > 50 years with radiographic evidence of mild to moderate knee OA (Kellgren Lawrence grade II & III 20) who met the ACR clinical 21,
• radiographic classification criteria or confirmation of mild to moderate radiographic evidence of knee OA from a personal physician
• not currently participating in another intervention study

Exclusion Criteria

• dementia (Mini-Mental State Examination [MMSE]< 24)
• active cancer other than skin cancer
• anemia (participants with an hematocrit (HCT)< 32 (or a hemoglobin below10) were excluded due to possible inability to adequately exercise or the increased potential for increased risk for serious adverse cardiovascular events)
• severe renal insufficiency (serum creat> 2)
• hepatic disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
experimental group	glucosamine chondritin & Physiotherapy	chondritin sulfate plus physiotherapy
control group	Glucosamine Chondroitin	chondritin sulfate 1500/1200mg

Primary Outcome Measures

Name	Time	Method
WOMAC	6 months	higher score means worst patient condition and lower score means better

Secondary Outcome Measures

Name	Time	Method
SF-36	6 months	higher score means better patient condition and lower score means worst

Trial Locations

Locations (1)

Muhammad Umar; 🇵🇰 Rawalpindi, Punjab, Pakistan