Influence of Transcranial Direct-current Stimulation on Cortical Plasticity in Healthy Older Adults
Trial Snapshot
- Phase
- Not Applicable
- Status
- Withdrawn
- Locations
- 1
- Primary Endpoint
- anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) in healthy older adults
Study Overview
Brief Summary
The aim of this study is to investigate whether the anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) in healthy older adults leads to an increase in cortical plasticity (change in motor evoked potentials (MEP) in mV).
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- Double (Participant, Investigator)
Eligibility Criteria
- Ages
- 50 Years to 80 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •right-handed according to the Oldfield Händigkeits inventory (lateralization index >70)(1971)
- •no obvious cognitive impairment (MMSE>26, Demtect>13)
- •age between 50 and 80 years
Exclusion Criteria
- •Severe neurological / psychiatric or pre-existing internist conditions because additional cognitive deficits are expected
- •Epilepsy, epileptic seizure in medical history
- •Cognitive deficit (MMSE <20)
- •Depressive episode (Beck Depression Inventory (BDI) > 12)
- •intake of centrally active drugs <3 months , particularly acetylcholinesterase inhibitors
- •Pregnancy
- •Pacemaker (contraindication for MRI)
- •Other metal parts in the body (contraindication for MRI)
Arms & Interventions
transcranial direct current stimulation
Intervention: transcranial direct current stimulation (Device)
sham stimulation
Intervention: sham stimulation (Device)
Outcomes
Primary Outcomes
anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) in healthy older adults
Time Frame: 1 week
to investigate whether the anodal transcranial direct current stimulation over the primary motor cortex (M1) in healthy older adults increases cortical plasticity (measured via motor evoked potentials)compared to sham stimulation
Secondary Outcomes
- Comparison of tDCS-induced changes in the learning success(1 week)
- Comparison of tDCS-induced changes on central cholinergic activity(1 week)
- genetic polymorphism, ApoE4(once)
- MR elastography(1 week)
Investigators
Agnes Flöel
Prof. Dr.
Charite University, Berlin, Germany