Effect of calcium and citrate dialysate concentrations on the calcification propensity in hemodialysis; a prospective randomized controlled cross-over trial.
Completed
- Conditions
- Calcification propensity of serum of hemodialysis patients. Vascular calcification.100132961003843010003216
- Registration Number
- NL-OMON44984
- Lead Sponsor
- Interne Geneeskunde, Nefrologie
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 20
Inclusion Criteria
Prevalent HD patients with a dialysis vintage of at least 3 months.
Hemodynamically stable on dialysis.
AV-fistula enabling double-needle vascular access or tunneled central venous dialysis catheter with a blood flow rate of at least 300 ml/min.
Age above 18 years of age.
Informed consent.
Exclusion Criteria
Withdrawal of consent
Acute intercurrent illness (infection, malignancy, cardiovascular event, uncontrolled diabetes)
Long QT syndrome
Frequent intra-dialytic hypotension (>10% of treatments)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>* Calcification propensity assessed by the transition time T50 from primary to<br /><br>secondary CPP by time-resolved nephelometry (T50). </p><br>
- Secondary Outcome Measures
Name Time Method <p>* Pulse wave velocity (PWV) measured with a SphygmoCor pulse wave velocity<br /><br>meter.<br /><br>* Heart rate variability (HRV) measured with a Taskforce monitor.<br /><br>* Total mass balances of calcium and phosphate by direct dialysis<br /><br>quantification.</p><br>