A Study Designed to Evaluate the Safety and Efficacy of Venetoclax Plus Dexamethasone (VenDex) Compared With Pomalidomide Plus Dexamethasone (PomDex) in Participants With t(11;14)-Positive Relapsed or Refractory Multiple Myeloma.
- Conditions
- Multiple Myeloma
- Interventions
- Registration Number
- NCT03539744
- Lead Sponsor
- AbbVie
- Brief Summary
A study designed tocompare progression-free survival (PFS) in participants with t(11;14)-positive MM treated with venetoclax in combination with dexamethasone versus pomalidomide in combination with dexamethasone.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 265
- Documented diagnosis of multiple myeloma (MM) based on standard International Myeloma Working Group (IMWG) criteria.
- Measurable disease at screening as defined per protocol.
- Has received at least 2 prior lines of therapy as described in the protocol.
- Has had documented disease progression on or within 60 days after completion of the last therapy.
- Has received at least 2 consecutive cycles of lenalidomide and be relapsed/refractory to lenalidomide, as defined per protocol.
- Has received at least 2 consecutive cycles of a proteasome inhibitor (PI).
- Has t(11;14)-positive status determined by an analytically validated fluorescent in situ hybridization (FISH) assay per centralized laboratory testing.
- An Eastern Cooperative Oncology Group (ECOG) performance status less than or equal to 2.
- Laboratory values (liver, kidney and hematology laboratory values) that meet criteria as described per protocol.
- History of treatment with venetoclax or another B-Cell Lymphoma (BCL)-2 inhibitor or pomalidomide.
- History of other active malignancies, including myelodysplastic syndromes (MDS), within the past 3 years (exceptions described in the protocol).
- Evidence of ongoing graft-versus-host disease (GvHD) if prior stem cell transplant (SCT).
- Prior treatment with any of the following: allogeneic or syngeneic SCT within 16 weeks prior to randomization; or autologous SCT within 12 weeks prior to randomization.
- Known central nervous system involvement of MM.
- Concurrent conditions as listed in the protocol.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Arm 1 VenDex Dexamethasone Venetoclax administered orally once daily (QD) plus dexamethasone administered orally once every week (Q1W) for each 28-day cycle. Arm 2 PomDex Dexamethasone Pomalidomide administered orally once daily (QD) on Days 1 - 21 for each 28-day cycle plus dexamethasone administered orally once every week (Q1W) for each 28-day cycle. Arm 1 VenDex Venetoclax Venetoclax administered orally once daily (QD) plus dexamethasone administered orally once every week (Q1W) for each 28-day cycle. Arm 2 PomDex Pomalidomide Pomalidomide administered orally once daily (QD) on Days 1 - 21 for each 28-day cycle plus dexamethasone administered orally once every week (Q1W) for each 28-day cycle.
- Primary Outcome Measures
Name Time Method Progression-Free Survival (PFS) Up to approximately 43 months from first randomization PFS is defined as the time in days from subject randomization to the date of the first documented progressive disease (PD) or death due to any cause, whichever occurs first.
- Secondary Outcome Measures
Name Time Method Time to Deterioration in Disease Symptoms Up to approximately 51 months from first randomization Time to deterioration in disease symptoms is measured by the disease symptom domain of the European Organization for Research and Treatment of Cancer Quality of Life Multiple Myeloma Module 20 (EORTC QLQ-MY20).
Time to Deterioration in Physical Functioning Up to approximately 51 months from first randomization Time to deterioration in physical functioning is measured by the physical functioning domain of European Organization for Research and Treatment of Cancer Quality of Life Core 30 Question Questionnaire (EORTC-QLQ-C30).
Change from Baseline in PROMIS Fatigue Score Up to approximately 51 months from first randomization Change from baseline in the Patient Reported Outcomes Measurement Information System (PROMIS) Fatigue Short Form 7a score.
Change from Baseline in BPI-SF Worst Pain Score Up to approximately 51 months from first randomization Change from baseline in the Brief Pain Inventory - Short Form (BPI-SF) worst pain score.
Change from Baseline in EuroQoL 5 Dimension 5 Level (EQ-5D-5L) Up to approximately 51 months from first randomization EQ-5D-5L consists of 2 components: the EQ-5D descriptive system and the EQ visual analog scale (VAS). The EQ-5D descriptive system comprises 5 dimensions: mobility, self-care, usual activities, pain/discomfort and anxiety/depression. The EQ VAS records the participant's self-rated health on a vertical VAS where the endpoints are labelled "The best health you can imagine" and "The worst health you can imagine."
Change from Baseline in European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30) Up to approximately 51 months from first randomization EORTC QLQ-C30 is a 30-item subject self-report questionnaire composed of both multi-item and single scales, including 5 functional scales (physical, role, emotional, social, and cognitive), 3 symptom scales (fatigue, nausea and vomiting, and pain), a global health status/quality of life scale, and 6 single items (dyspnea, insomnia, appetite loss, constipation, diarrhea, and financial difficulties).
Change from Baseline in European Organization for Research and Treatment of Cancer Quality of Life Multiple Myeloma Module 20 (EORTC QLQ-MY20) Up to approximately 51 months from first randomization EORTC QLQ-MY20 includes scales for disease symptoms, side effects of treatment, future perspective, and body image. Values for each scale range from 0 to 100.
Duration of response (DOR) Up to approximately 43 months from first randomization DOR for a participant is defined as the number of days from the date of first documented response (PR or better) to the date of first documented PD or death due to multiple myeloma, whichever occurs first.
Overall Response Rate (ORR) Up to approximately 43 months from first randomization ORR is defined as the percentage of participants with documented best response (sCR, CR, VGPR or partial response \[PR\]) prior to first documented PD.
Very Good Partial Response or Better Response Rate (VGPR) Up to approximately 43 months from first randomization VGPR or better response rate is defined as the proportion of participants with documented stringent complete response (sCR), complete response (CR), or VGPR.
Overall survival (OS) Up to approximately 51 months from first randomization OS is defined as the number of days from the date that the participant was randomized to the date of the participant's death.
Minimal Residual Disease (MRD) Negativity Rate Up to approximately 43 months from first randomization MRD defined as the percentage of participants with MRD negativity status. MRD negativity will be defined at 10\^-5 threshold as measured by centralized testing of bone marrow aspirate samples by next generation sequencing (NGS).
Time to Disease Progression (TTP) Up to approximately 43 months from first randomization TTP for a participant is defined as the number of days from the date of randomization to the date of first documented PD or death due to multiple myeloma, whichever occurs first.
Time to Response (TTR) Up to approximately 43 months from first randomization TTR for a participant is defined as the number of days from the date of randomization to the date of first documented response (PR or better).
Cmax of Venetoclax Up to approximately 225 days from initial dose Maximum plasma concentration (Cmax) of venetoclax
Trough Concentration (Ctrough) of Venetoclax Up to approximately 225 days from initial dose Observed plasma concentration at trough (Ctrough) of venetoclax.
Number of Participants With Adverse Events (AEs) Up to approximately 51 months from first randomization An adverse event (AE) is defined as any untoward medical occurrence in a patient or clinical investigation participant administered a pharmaceutical product which does not necessarily have a causal relationship with this treatment. The investigator assesses the relationship of each event to the use of study.
Trial Locations
- Locations (180)
Duplicate_Herlev Hospital /ID# 223221
🇩🇰Herlev, Hovedstaden, Denmark
Duplicate_University of Arizona Cancer Center - North Campus /ID# 218407
🇺🇸Tucson, Arizona, United States
VA Central California Health Care System /ID# 200047
🇺🇸Fresno, California, United States
University of California, Los Angeles /ID# 171524
🇺🇸Los Angeles, California, United States
Rocky Mountain Regional VA Medical Center/Eastern Colorado Health Care System /ID# 222904
🇺🇸Aurora, Colorado, United States
Mayo Clinic /ID# 200075
🇺🇸Jacksonville, Florida, United States
Cleveland Clinic Florida /ID# 208884
🇺🇸Weston, Florida, United States
Duplicate_Norton Cancer Institute /ID# 200834
🇺🇸Louisville, Kentucky, United States
University of Maryland, Baltimore /ID# 217422
🇺🇸Baltimore, Maryland, United States
Boston Medical Center /ID# 223606
🇺🇸Boston, Massachusetts, United States
Barbara Ann Karmanos Cancer In /ID# 201377
🇺🇸Detroit, Michigan, United States
Duplicate_Henry Ford Hospital /ID# 171531
🇺🇸Detroit, Michigan, United States
Mayo Clinic - Rochester /ID# 201091
🇺🇸Rochester, Minnesota, United States
Columbia University Medical Center /ID# 200715
🇺🇸New York, New York, United States
Fairview Hospital - Moll Pavilion /ID# 208919
🇺🇸Cleveland, Ohio, United States
Cleveland Clinic Main Campus /ID# 202247
🇺🇸Cleveland, Ohio, United States
UPMC Hillman Cancer Ctr /ID# 200063
🇺🇸Pittsburgh, Pennsylvania, United States
MD Anderson Cancer Center at Texas Medical Center /ID# 200060
🇺🇸Houston, Texas, United States
Huntsman Cancer Institute /ID# 218406
🇺🇸Salt Lake City, Utah, United States
VA Puget Sound Health Care System /ID# 222708
🇺🇸Seattle, Washington, United States
Liverpool Hospital /ID# 202431
🇦🇺Liverpool, New South Wales, Australia
Sydney Adventist Hospital /ID# 222874
🇦🇺Wahroonga, New South Wales, Australia
Wollongong Hospital /ID# 205545
🇦🇺Wollongong, New South Wales, Australia
ICON Cancer Care - Townsville /ID# 206565
🇦🇺Hyde Park, Queensland, Australia
Icon Cancer Centre /ID# 205663
🇦🇺South Brisbane, Queensland, Australia
The Queen Elizabeth Hospital /ID# 202432
🇦🇺Woodville South, South Australia, Australia
Perth Blood Institute Ltd /ID# 206649
🇦🇺Nedlands, Western Australia, Australia
Arthur J. E. Child Comprehensive Cancer Centre /ID# 218846
🇨🇦Calgary, Alberta, Canada
BC Cancer - Vancouver /ID# 222804
🇨🇦Vancouver, British Columbia, Canada
QE II Health Sciences Centre /ID# 218883
🇨🇦Halifax, Nova Scotia, Canada
CISSS-CA (Centre Integre de sante et de services sociaux de Chaudiere-Appalache) /ID# 218887
🇨🇦Levis, Quebec, Canada
Beijing Chaoyang Hospital,Capital Medical University /ID# 216014
🇨🇳Beijing, Beijing, China
Peking University Third Hospital /ID# 216371
🇨🇳Beijing, Beijing, China
Peking Union Medical College Hospital (East) - Dongdan Campus /ID# 216040
🇨🇳Beijing, Beijing, China
Sun Yat-Sen University Cancer Center /ID# 223828
🇨🇳Guangzhou, Guangdong, China
Guangdong Provincial People's Hospital /ID# 215860
🇨🇳Guangzhou, Guangdong, China
Henan Cancer Hospital /ID# 215987
🇨🇳Zhengzhou, Henan, China
Union Hospital Tongji Medical College Huazhong University of Science and Technol /ID# 215850
🇨🇳Wuhan, Hubei, China
Nanjing Drum Tower Hospital /ID# 223143
🇨🇳Nanjing, Jiangsu, China
The First Affiliated Hospital of Soochow University /ID# 216094
🇨🇳Suzhou, Jiangsu, China
The First Affiliated Hospital of Nanchang University /ID# 216954
🇨🇳Nanchang, Jiangxi, China
The First Hospital of China Medical University /ID# 215996
🇨🇳Shenyang, Liaoning, China
Shengjing Hospital of China Medical University /ID# 223435
🇨🇳Shenyang, Liaoning, China
Ruijin Hospital, Shanghai Jiaotong University School of Medicine /ID# 216643
🇨🇳Shanghai, Shanghai, China
Shanghai Tongji Hospital /ID# 218865
🇨🇳Shanghai, Shanghai, China
West China Hospital, Sichuan University /ID# 216647
🇨🇳Chengdu, Sichuan, China
Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sc /ID# 216041
🇨🇳Tianjin, Tianjin, China
Tianjin Medical University Cancer Institute & Hospital /ID# 223550
🇨🇳Tianjin, Tianjin, China
Aalborg University Hospital /ID# 223220
🇩🇰Aalborg, Nordjylland, Denmark
The First Affiliated Hospital, Zhejiang University School of Medicine /ID# 215989
🇨🇳Hangzhou, Zhejiang, China
The First Affiliated Hospital, Zhejiang University School of Medicine /ID# 218691
🇨🇳Hangzhou, Zhejiang, China
The First Affiliated Hospital of Wenzhou Medical University /ID# 218953
🇨🇳Wenzhou, Zhejiang, China
Beijing Chaoyang Hospital, Capital Medical University(West campus) /ID# 234033
🇨🇳Beijing, China
Fakultní Nemocnice Brno - Jihlavská /ID# 204512
🇨🇿Brno, Brno-mesto, Czechia
Fakultní nemocnice Hradec Králové - Sokolská /ID# 221291
🇨🇿Hradec Králové, Hradec Kralove, Czechia
Fakultni Nemocnice Ostrava /ID# 204515
🇨🇿Ostrava, Ostrava-mesto, Czechia
Fakultni nemocnice Olomouc /ID# 221290
🇨🇿Olomouc, Czechia
Vseobecna fakultni nemocnice v Praze /ID# 221166
🇨🇿Praha, Czechia
Odense University Hospital /ID# 223217
🇩🇰Odense, Syddanmark, Denmark
Sygehus Lillebalt, Vejle /ID# 223216
🇩🇰Vejle, Syddanmark, Denmark
Duplicate_Roskilde Hospital /ID# 223366
🇩🇰Roskilde, Denmark
Hopital Pitie Salpetriere /ID# 214173
🇫🇷Paris Cedex 13, Ile-de-France, France
Duplicate_CHU Grenoble - Hopital Michallon /ID# 223182
🇫🇷La Tronche, Isere, France
CHU Reims - Hôpital Robert Debre /ID# 233907
🇫🇷Reims CEDEX, Marne, France
CHRU Nancy - Hopitaux de Brabois /ID# 201076
🇫🇷Vandoeuvre-les-Nancy, Meurthe-et-Moselle, France
CHRU Lille - Hopital Claude Huriez /ID# 202213
🇫🇷Lille, Nord, France
Hopitaux Universitaires Henri Mondor - Hopital Henri Mondor /ID# 202211
🇫🇷Creteil, Paris, France
CHU de Nantes, Hotel Dieu -HME /ID# 200099
🇫🇷Nantes, Pays-de-la-Loire, France
HCL - Hopital Lyon Sud /ID# 200097
🇫🇷Pierre Benite CEDEX, Rhone, France
Centre Henri Becquerel /ID# 223186
🇫🇷Rouen, Seine-Maritime, France
CH Henri Duffaut /ID# 234154
🇫🇷Avignon CEDEX 9, Vaucluse, France
Robert-Bosch-Krankenhaus /ID# 223947
🇩🇪Stuttgart, Baden-Wuerttemberg, Germany
Universitaetsklinikum Tuebingen /ID# 238646
🇩🇪Tubingen, Baden-Wuerttemberg, Germany
Universitaetsklinikum Wuerzburg /ID# 200055
🇩🇪Wuerzburg, Bayern, Germany
Klinikum Chemnitz gGmbH /ID# 233797
🇩🇪Chemnitz, Sachsen, Germany
Universitaetsklinikum Schleswig-Holstein Campus Kiel /ID# 201830
🇩🇪Kiel, Schleswig-Holstein, Germany
Universitaetsklinikum Jena /ID# 201254
🇩🇪Jena, Thueringen, Germany
Charite Universitaetsklinikum Berlin - Campus Benjamin Franklin /ID# 200051
🇩🇪Berlin, Germany
Universitaetsklinikum Hamburg-Eppendorf /ID# 215495
🇩🇪Hamburg, Germany
Asklepios Klinik Altona /ID# 222506
🇩🇪Hamburg, Germany
Alexandra General Hospital /ID# 202386
🇬🇷Athens, Attiki, Greece
University General Hospital of Heraklion PA.G.N.I /ID# 222879
🇬🇷Heraklion, Kriti, Greece
General Hospital of Athens Evaggelismos and Ophthalmiatrio of Athens Polyclinic /ID# 213982
🇬🇷Athens, Greece
University Gen Hosp of Patra /ID# 201691
🇬🇷Patras, Greece
Theageneio Anticancer Hospital /ID# 213983
🇬🇷Thessaloniki, Greece
General Hospital of Thessaloniki George Papanikolaou /ID# 201692
🇬🇷Thessaloniki, Greece
Rambam Health Care Campus /ID# 169678
🇮🇱Haifa, H_efa, Israel
Bnai Zion Medical Center /ID# 169466
🇮🇱Haifa, H_efa, Israel
The Lady Davis Carmel Medical Center /ID# 222969
🇮🇱Haifa, H_efa, Israel
Duplicate_Assuta Ashdod Medical Center /ID# 222968
🇮🇱Ashdod, HaDarom, Israel
Soroka University Medical Center /ID# 218768
🇮🇱Be'er Sheva, HaDarom, Israel
The Chaim Sheba Medical Center /ID# 169778
🇮🇱Ramat Gan, Tel-Aviv, Israel
Tel Aviv Sourasky Medical Center /ID# 169437
🇮🇱Tel Aviv, Tel-Aviv, Israel
Hadassah /ID# 169474
🇮🇱Jerusalem, Yerushalayim, Israel
Rabin Medical Center /ID# 244611
🇮🇱Petah Tikva, Israel
Duplicate_IRCCS AOU di Bologna - Policlinico Sant'Orsola-Malpighi /ID# 170952
🇮🇹Bologna, Emilia-Romagna, Italy
A.O.U. CITTA' DELLA SALUTE E DELLA SCIENZA DI TORINO - Ospedale Molinette /ID# 170962
🇮🇹Torino, Piemonte, Italy
Irccs-Crob /Id# 170955
🇮🇹Rionero In Vulture, Potenza, Italy
Azienda Ospedaliero Universitaria delle Marche /ID# 170950
🇮🇹Ancona, Italy
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico /ID# 212498
🇮🇹Milano, Italy
Azienda Ospedaliera Ospedali Riuniti Villa Sofia Cervello /ID# 222988
🇮🇹Palermo, Italy
Azienda Ospedaliera Santa Maria Terni /ID# 170948
🇮🇹Terni, Italy
Nagoya City University Hospital /ID# 170880
🇯🇵Nagoya shi, Aichi, Japan
The Jikei University Kashiwa Hospital /ID# 223031
🇯🇵Kashiwa-shi, Chiba, Japan
Kyushu University Hospital /ID# 171117
🇯🇵Fukuoka-shi, Fukuoka, Japan
Ogaki Municipal Hospital /ID# 171043
🇯🇵Ogaki-shi, Gifu, Japan
Gunma University Hospital /ID# 170966
🇯🇵Maebashi-shi, Gunma, Japan
Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital /ID# 171255
🇯🇵Hiroshima-shi, Hiroshima, Japan
Kobe City Medical Center General Hospital /ID# 170992
🇯🇵Kobe-shi, Hyogo, Japan
Duplicate_National Hospital Organization Mito Medical Center /ID# 171187
🇯🇵Higashi Ibaraki-gun, Ibaraki, Japan
Hitachi General Hospital /ID# 200843
🇯🇵Hitachi-shi, Ibaraki, Japan
Iwate Medical University Hospital /ID# 222849
🇯🇵Shiwa-gun, Iwate, Japan
Tohoku University Hospital /ID# 201935
🇯🇵Sendai-shi, Miyagi, Japan
Okayama Medical Center /ID# 200119
🇯🇵Okayama-shi, Okayama, Japan
Japanese Red Cross Osaka Hospital /ID# 171493
🇯🇵Osaka-shi, Osaka, Japan
The University of Osaka Hospital /ID# 201966
🇯🇵Suita-shi, Osaka, Japan
Tokushima University Hospital /ID# 202571
🇯🇵Tokushima-shi, Tokushima, Japan
The Jikei University Hospital /ID# 239014
🇯🇵Minato-ku, Tokyo, Japan
Japanese Red Cross Medical Center /ID# 171256
🇯🇵Shibuya-ku, Tokyo, Japan
Yamagata University Hospital /ID# 238329
🇯🇵Yamagata-shi, Yamagata, Japan
Duplicate_Gachon University Gil Medical Center /ID# 202827
🇰🇷Incheon, Gyeonggido, Korea, Republic of
Seoul National University Hospital /ID# 202711
🇰🇷Seoul, Seoul Teugbyeolsi, Korea, Republic of
Samsung Medical Center /ID# 202710
🇰🇷Seoul, Seoul Teugbyeolsi, Korea, Republic of
The Catholic University of Korea, Seoul St. Marys Hospital /ID# 234045
🇰🇷Seoul, Seoul Teugbyeolsi, Korea, Republic of
Ulsan University Hospital /ID# 222716
🇰🇷Ulsan, Ulsan Gwang Yeogsi, Korea, Republic of
Yonsei University Health System Severance Hospital /ID# 202709
🇰🇷Seoul, Korea, Republic of
Moscow State budget healthcare /ID# 169685
🇷🇺Moscow, Moskva, Russian Federation
Research Institute of Fundamental and Clinical Immunology /ID# 223594
🇷🇺Novosibirsk, Novosibirskaya Oblast, Russian Federation
LLC Novaya Klinika /ID# 169689
🇷🇺Pyatigorsk, Stavropol Skiy Kray, Russian Federation
City Clinical Hospital #52 /ID# 206289
🇷🇺Moscow, Russian Federation
Leningrad Regional Clinical Hospital /ID# 202776
🇷🇺Saint Petersburg, Russian Federation
Almazov National Medical Research Centre /ID# 169681
🇷🇺Sankt-Peterburg, Russian Federation
Tula Regional Clinical Hospital /ID# 223226
🇷🇺Tula, Russian Federation
National University Hospital /ID# 203988
🇸🇬Singapore, Singapore
Singapore General Hospital /ID# 202131
🇸🇬Singapore, Singapore
Tan Tock Seng Hospital /ID# 204374
🇸🇬Singapore, Singapore
Hospital Universitari Son Espases /ID# 222889
🇪🇸Palma de Mallorca, Illes Balears, Spain
Hospital Costa del Sol /ID# 234083
🇪🇸Marbella, Malaga, Spain
Complejo Hospitalario Universitario Ourense /ID# 222876
🇪🇸Orense, Ourense, Spain
Hospital Universitario Canarias /ID# 238452
🇪🇸San Cristóbal de La Laguna, Santa Cruz De Tenerife, Spain
Hospital Universitario Vall d'Hebron /ID# 218106
🇪🇸Barcelona, Spain
Instituto Catalan de Oncologia (ICO) Girona /ID# 171311
🇪🇸Girona, Spain
Hospital de Leon /ID# 233878
🇪🇸Leon, Spain
Hospital Universitario Fundacion Jimenez Diaz /ID# 171304
🇪🇸Madrid, Spain
Hospital Universitario 12 de Octubre /ID# 171288
🇪🇸Madrid, Spain
Hospital Universitario La Paz /ID# 218107
🇪🇸Madrid, Spain
Hospital Universitario de Salamanca /ID# 171294
🇪🇸Salamanca, Spain
Hospital Universitario Virgen del Rocio /ID# 171286
🇪🇸Sevilla, Spain
Hospital General Universitario de Toledo /ID# 222887
🇪🇸Toledo, Spain
Hospital Universitario y Politecnico La Fe /ID# 234019
🇪🇸Valencia, Spain
Sunderby sjukhus /ID# 201314
🇸🇪Lulea, Norrbottens Lan, Sweden
Sodra Alvsborgs sjukhus /ID# 213061
🇸🇪Boras, Vastra Gotalands Lan, Sweden
Duplicate_Universitetssjukhuset Linköping /ID# 200789
🇸🇪Linkoping, Vastra Gotalands Lan, Sweden
Uddevalla sjukhus /ID# 201315
🇸🇪Uddevalla, Vastra Gotalands Lan, Sweden
Cukurova Universitesi Tip Fakultesi /ID# 201955
🇹🇷Saricam Adana, Adana, Turkey
Izmir Ekonomi Universitesi Ozel Medicalpoint Hastanesi /ID# 201954
🇹🇷Karsiyaka, Izmir, Turkey
Dr. Abdurrahman Yurtaslan Ankara Onkoloji Egitim ve Arastirma Hastanesi /ID# 201956
🇹🇷Ankara, Turkey
Gazi University Medical Faculty /ID# 222698
🇹🇷Ankara, Turkey
Ankara Univ Medical Faculty /ID# 201881
🇹🇷Ankara, Turkey
Istanbul University Istanbul Medical Faculty /ID# 201953
🇹🇷Istanbul, Turkey
Bagcilar Medipol Mega Universite Hastanesi /ID# 222914
🇹🇷Istanbul, Turkey
Marmara Universitesi Pendik Egitim ve Arastirma Hastanesi /ID# 201952
🇹🇷Istanbul, Turkey
Ege University Medical Faculty /ID# 222697
🇹🇷Izmir, Turkey
Communal Nonprofit Enterprise Cherkasy Regional Oncology Dispensary /ID# 223943
🇺🇦Cherkasy, Cherkaska Oblast, Ukraine
Communal non-profit enterprise Regional Center of Oncology /ID# 223945
🇺🇦Kharkiv, Kharkivska Oblast, Ukraine
MNI Khmelnytskyi Regional Hospital of Khmelnytskyi Regional Council /ID# 223942
🇺🇦Khmelnytskyi, Ukraine
National Cancer Institute /ID# 223944
🇺🇦Kyiv, Ukraine
SI Institute of Blood Pathology and Transfusion Medicine of NAMS of Ukraine /ID# 223941
🇺🇦Lviv, Ukraine
Addenbrooke's Hospital /ID# 223097
🇬🇧Cambridge, Cambridgeshire, United Kingdom
Hammersmith Hospital /ID# 171446
🇬🇧London, England, United Kingdom
University College London Hospital /ID# 171428
🇬🇧London, Greater London, United Kingdom
Norfolk and Norwich University Hospitals NHS Foundation Trust /ID# 218213
🇬🇧Norwich, Norfolk, United Kingdom
Duplicate_Nottingham University Hospitals NHS Trust /ID# 223292
🇬🇧Nottingham, Nottinghamshire, United Kingdom
Duplicate_NHS Greater Glasgow and Clyde /ID# 202199
🇬🇧Glasgow, Scotland, United Kingdom
Duplicate_University Hospitals North Midlands - Royal Stoke University Hospital /ID# 218355
🇬🇧Stoke-on-Trent, Staffordshire, United Kingdom
Duplicate_Duplicate_Lewisham and Greenwich NHS Trust /ID# 171445
🇬🇧London, United Kingdom
Manchester University NHS Foundation Trust /ID# 171440
🇬🇧Manchester, United Kingdom
Portsmouth Hospitals University NHS Trust /ID# 171444
🇬🇧Portsmouth, United Kingdom
Royal Berkshire NHS Foundation Trust /ID# 217835
🇬🇧Reading, United Kingdom
Duplicate_Sheffield Teaching Hospitals NHS Foundation Trust - Royal Hallamshire /ID# 171447
🇬🇧Sheffield, United Kingdom