Double Blind Randomized Study of Morphine Analgesia in Patients With Acute Appendicitis
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 71
- 试验地点
- 2
- 主要终点
- Pain Intensity
研究概览
简要总结
The purpose of the study is to evaluate morphine effect on pain reduction and diagnostic accuracy in patients admitted to emergency ward with the diagnosis of acute appendicitis.
详细描述
Analgesic administration for pain control in patients with acute abdominal pain, regarding acute appendicitis, is controversial. Despite the results previous studies indicating the safeness of analgesic use in ED for acute abdominal pain, physicians still prefer to postpone their use after performing surgical evaluations. Since many patients admitted to ED are unlikely to receive prompt surgical consultation, many of them need pain relief to prevent unnecessary suffering. On the other hand such pain relief must not interfere with the diagnosis and treatment of patients and do not cause any complications. Morphine is a common and effective analgesic which, if shown to have no effect on correct diagnosis of acute abdomen, can be used for this purpose.
Thus we evaluated morphine effect on pain reduction and diagnostic accuracy in patients admitted to ED with the diagnosis of acute appendicitis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Double
入排标准
- 年龄范围
- 13 Years 至 75 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •clinical signs of acute appendicitis
- •planned for appendectomy
- •supposed to wait for at least 1 hour in the ED before operation
排除标准
- •suspicion to perforated appendicitis
- •being under the age of 13
- •pregnancy (according to history and ß-HCG result)
- •opium addiction
- •systolic blood pressure of less than 90 mmHG
- •known cases of chronic obstructive pulmonary disease (COPD)
- •known sensitivity to morphine
- •history of sickle cell disease
- •self administration of analgesics before enrollment
- •refusal to participate
结局指标
主要结局
Pain Intensity
次要结局
- Diagnostic Accuracy