Non-surgical Peridontal Treatment on Cardiovascular Risk Markers

Not Applicable

Completed

• Conditions: Cardiovascular Risk Markers; Chronic Periodontitis
• Interventions: Other: Non-surgical periodontal treatment

• Registration Number: NCT04540328
• Lead Sponsor: Kırıkkale University

Brief Summary

The study evaluates the influence of non-surgical mechanical periodontal treatment in patients with severe chronic periodontitis on inflammatory markers related to risk for cardiovascular diseases

Detailed Description

A total of 80 non-smokers with systemically healthy, including 40 patients with severe chronic periodontitis and 40 periodontally health subjects were included into the present study. The probing depth, clinical attachment level, plaque index, gingival index and blood samples were collected at baseline and at the 3rd months after treatment and the serum levels of asymmetric dimethylarginine (ADMA), endothelial nitric oxide synthase (eNOS), homocysteine (Hcy), monocyte chemoattractant protein-1 (MCP-1) were determined with enzyme-linked immunosorbent assay (ELISA).

Study Timeline

• Study Start: 2015-08
• Primary Completion: 2016-02
• Study Completion: 2017-08
• Study First Submitted: 2018-03-07
• Status Verified: 2020-09
• Study First Submitted QC: 2020-09-01
• Last Update Submitted: 2020-09-01
• Study First Posted: 2020-09-07
• Last Update Posted: 2020-09-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

Clinical diagnosis of severe chronic periodontitis

Clinical diagnosis of periodontal health

Exclusion Criteria

Systemic diseases such as diabetes, cardiovascular disease

Periodontal treatment within the previous year

Drugs such as systemic steroids, non-steroidal anti-inflammatory drugs, immunosuppressants, hormone drugs, contraceptives, anticoagulants, cholesterol regulating drugs, systemic antibiotics, antioxidants within the previous 3 months

Pregnant or lactating

Consumed alcohol

Smoker

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Non-surgical peridontal treatment	Non-surgical periodontal treatment	Patients with chronic periodontitis received non-surgical periodontal treatment, including scaling and root planing and polishing within 14 days under local anesthesia with manual and ultrasonic devices and standardized oral hygiene instructions including methods of tooth-brushing and interdental cleaning were also given to each one. A professional supragingival plaque control was applied on a regular basis every month.

Primary Outcome Measures

Name	Time	Method
Endothelial nitric oxide synthase (eNOS)	At the 3rd months after non-surgical periodontal treatment	Serum Concentration (pg/mL)
Homocysteine (Hcy)	At the 3rd months after non-surgical periodontal treatment	Serum Concentration (nmol/mL)
Monocyte chemoattractant protein-1 (MCP-1)	At the 3rd months after non-surgical periodontal treatment	Serum Concentration (ng/mL)
Asymmetric dimethylarginine (ADMA)	At the 3rd months after non-surgical periodontal treatment	Serum Concentration (pg/mL)

Secondary Outcome Measures

Name	Time	Method
Clinical periodontal parameter	At the 3rd months after non-surgical periodontal treatment	Clinical attachment level (mm)