Auto-titrating continuous positive airway pressure in patients with chronic heart failure and obstructive sleep apnoea

Not Applicable

Completed

• Conditions: Chronic heart failure and obstructive sleep apnoea; Circulatory System; Heart failure

• Registration Number: ISRCTN24943566
• Lead Sponsor: niversity of Edinburgh (UK)

Brief Summary

2007 Results article in http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=17470670

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2005-04-01
• Study Start: 2006-11-20
• Last Update Posted: 28 November 2022

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 26

Inclusion Criteria

1. Stable symptomatic CHF (Left Ventricular Ejection Fraction [LVEF] less than 45%)
2. On optimal medical therapy with obstructive sleep apnoea (Apnea-Hypopnea Index [AHI] more than or equal to 15)

Exclusion Criteria

1. Acute coronary syndrome less than 3/12
2. Primary valvular heart disease
3. Sustained ventricular arrhythmias
4. Stroke with residual neurological deficit

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Changes in peak maximal oxygen uptake (VO2) and six-minute walk distance.

Secondary Outcome Measures

Name	Time	Method
<br> Changes in:<br> 1. LVEF<br> 2. Minute ventilation versus carbon dioxide production (VE/VCO2) slope<br> 3. Plasma neurohormonal makers<br> 4. Quality of life<br>