Intermittent Fasting vs. High-Intensity Interval Training on Lipid Profile in Obese Patients
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Cairo University
- Enrollment
- 80
- Locations
- 1
- Primary Endpoint
- lipid profile
Study Overview
Brief Summary
we aimed to ascertain the effect of intermittent fasting (IF) vs. high-intensity interval training (HIIT) on the lipid profile and waist circumference (WC) of obese individuals.
Detailed Description
Subjects and Methods: This study included 40 obese individuals of both genders aged 35-50 years with an abnormal lipid profile. The patients were allocated at random to either Group A or B, with both groups receiving medical treatment. Group A followed the IF regime, while Group B performed HIIT on the treadmill three times weekly, with an intervention duration of six weeks for both groups. Body mass index (BMI), WC, levels of total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL), alongside the Framingham risk score (FRS) were the evaluated variables.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Eligibility Criteria
- Ages
- 35 Years to 50 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Inclusion criteria were as follows: (1) A BMI of 30 -40 kg/m2; (2) abnormal lipid profile, with a TC level > 200 mg/dL, an LDL > 100 mg/dL, a TC level > 150 mg/dL, and an HDL < 40 mg/dL; (3) steady vital signs, including blood pressure, respiration rate, and temperature at a baseline level.
Exclusion Criteria
- •The exclusion criteria included patients with the following medical conditions: cancer, unstable angina, uncontrolled cardiac rhythm, decompensated heart failure, persistent systolic blood pressure > 200 mmHg, persistent diastolic blood pressure > 120 mmHg, acute pericarditis or myocarditis, severe restrictive lung disease, chronic chest infection, severe obstructive lung disease, pregnant women, neurological disorders that affect balance and mentality (e.g., epilepsy), orthopedic or neurological problems that interfere with exercises, unstable endocrinal disorders, congenital or acquired lower limb deformity, kidney disease, infectious disease, immune disease, hearing impairment or mental disorder, uncontrolled T2DM.
Arms & Interventions
Group A (IF group)
Group A followed the intermittent fasting( IF) regime ,with an intervention duration of six weeks for both groups
Intervention: intermittent fasting (Behavioral)
Group B performed High-intensity interval training( HIIT)
High-intensity interval training performed on the treadmill three times weekly, with an intervention duration of six weeks for both groups
Intervention: low volume high intensity interval training (Behavioral)
Outcomes
Primary Outcomes
lipid profile
Time Frame: lipid profile will be measured at baseline, and it will be measured again after six weeks
A 5 mL fasting venous blood sample was collected following an eight-hour overnight fast, and LDL, HDL, TG, and TC levels were measured.
Secondary Outcomes
- waist circumference(waist circumference will be measured at baseline, and it will be measured again after six weeks)
- The Framingham risk score (FRS)(The Framingham risk score (FRS) will be measured at baseline, and it will be measured again after six weeks)
Investigators
Heba Ahmed Mousa
lecturer of physical therapy
Cairo University