Nutrition Ameliorates the Muscle Loss of Pre-sarcopenia in Elderly
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Appendicular Skeletal Muscle Index (ASMI)
研究概览
简要总结
This study evaluates the effects of a 12-week leucine-enriched protein supplementation in adults aged 60 years and more. Participants will undergo assessments of muscle mass and function, as well as metabolic profiles in blood, urine, and feces before and after the intervention.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 60 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Willing to provide written informed consent.
- •Participants who attend health check-ups at Songshan District, Taipei City, or at the Wellness Cultural Village, or who have participated in the pilot study.
- •Adults aged 60 years or older, male or female.
- •Able to ambulate independently.
- •Meets at least one of the following sarcopenia criteria:
- •Grip strength: Men < 28 kg; Women < 18 kg Gait speed: < 1.0 m/s Muscle mass (appendicular skeletal muscle mass / height²): Men < 7.0 kg/m²; Women < 5.7 kg/m²
排除标准
- •Impaired renal function.
- •Allergy or intolerance to protein supplements.
- •Currently undergoing cancer treatment.
- •Autoimmune diseases.
- •Assessed by a physician as unsuitable to participate.
研究组 & 干预措施
Protein Supplementation Group
干预措施: Participants consume two sachets daily over a 12-week intervention period. (Dietary Supplement)
结局指标
主要结局
Appendicular Skeletal Muscle Index (ASMI)
时间窗: Baseline and 12 weeks after intervention
Muscle mass was assessed using bioelectrical impedance analysis (Tanita MC-780MA). The appendicular skeletal muscle index (ASMI, kg/m2) was calculated as appendicular skeletal muscle mass (ASM, kg) divided by height squared (m²).
Handgrip Strength (HGS)
时间窗: Baseline and 12 weeks after intervention
Functional performance was evaluated by handgrip strength (HGS, kg), measured with a digital hand dynamometer.
Gait speed (m/s)
时间窗: Baseline and 12 weeks after intervention
Gait speed was assessed as the time required to walk a 4 meters, expressed in meters per second (m/s).
次要结局
未报告次要终点