Analysis of Screen-detected Lung Cancers' Genomic Traits
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 526
- 试验地点
- 4
- 主要终点
- Genomic exploratory research
研究概览
简要总结
Prospective, observational cohort study of patients undergoing surgical resection for low dose CT (LDCT) screen-detected lung cancer (detected through the SUMMIT study- ClinicalTrials.gov Identifier: NCT03934866/ lung screening programmes), in which translational research is a fundamental aspect.
详细描述
The ASCENT study seeks to examine the genomic signatures of screen-detected cancers, in order to categorise the biological behaviour of such lesions and correlate this against non-invasive biological and radiological parameters. From these data, the plan is to explore strategies to characterise LDCT-detected cancers through non-invasive means, which the researchers believe may prove key in mitigating potential screening-associated harms.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Other
入排标准
- 年龄范围
- 50 Years 至 77 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosed with confirmed lung cancer or probable lung cancer via LDCT screening.
- •Planned for, or completed primary surgical resection either for histologically confirmed lung cancer, or strongly suspected lung cancer.
- •Able to provide written informed consent (or verbal informed consent for participants consenting to retrospective diagnostic samples and data collection only).
排除标准
- •Treatment with neoadjuvant therapy for current lung malignancy as per local MDT treatment decision.
- •Known Active Human Immunodeficiency Virus (HIV), Hepatitis B virus, Hepatitis C Virus or Syphilis.
结局指标
主要结局
Genomic exploratory research
时间窗: 4 years
Measuring the differences in chromosomal instability between fast- and slow-growing screen detected cancers, quantified by weighted genome integrity index (WGII) derived from whole exome sequencing (WES) data
次要结局
未报告次要终点