Anticoagulation in frail elderly patients with atrial fibrillation.
Recruiting
- Conditions
- Frail elderly, atrial fibrillation, oral anticoagulants (vitamin K antagonists, NOACs), bleeding complications.<br />Kwetsbare ouderen, atriumfibrilleren, orale antistolling (VKA's, NOAC's), bloedingscomplicaties.
- Registration Number
- NL-OMON22182
- Lead Sponsor
- Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands.
- Brief Summary
Follows.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 2750
Inclusion Criteria
1. Age > 75 years;
2. Currently managed on VKA treatment for AF by one of the participating thrombosis services;
Exclusion Criteria
1. Renal impairment, i.e. an eGFR below 30 ml/min/1.73m2. These patients will not be randomized for our main objective, but will be followed-up observationally in order to evaluate one of our secondary objectives (risk factors for bleeding);
2. Valvular AF: AF in the presence of a mechanical heart valve, and/or severe mitral valve stenosis;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method