evaluation of N-acetylcysteine on nitrosative stress in Rheumatoid arthritis patients

Phase 3

Recruiting

• Conditions: Rheumatoid arthritis.; Rheumatoid arthritis, unspecified

• Registration Number: IRCT2017073022965N12
• Lead Sponsor: Vice Chancellor for research of Hamadan University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 52

Inclusion Criteria

inclusion criteria: Patients with active rheumatoid arthritis; Normal renal function(serum creatinine lower than 2); Ability of taking oral n-acetylcysteine; Normal liver function
exclusion criteria: Renal dysfunction; Liver dysfunction; Active infection; Mental or cognitive problem; Disability of taking oral drug; Taking antioxidant agents or anti-inflammatory drugs in previous month; Patients with other inflammatory diseases; Patients whom experience adverse drug reactions; Pregnant or lactating patients

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
itric oxide. Timepoint: at baseline, at the end of study. Method of measurement: serum level.;Lipid peroxidation. Timepoint: at baseline, at the end of study. Method of measurement: serum level.;Thiol groups. Timepoint: at baseline, at the end of study. Method of measurement: serum level.;Total antioxidant capacity. Timepoint: at baseline, at the end of study. Method of measurement: serum level.