A Study of Tucatinib or Placebo With Trastuzumab and Pertuzumab for Metastatic HER2+ Breast Cancer
- Conditions
- HER2 Positive Breast Cancer
- Interventions
- Registration Number
- NCT05132582
- Lead Sponsor
- Seagen, a wholly owned subsidiary of Pfizer
- Brief Summary
This study is being done to see if tucatinib works better than placebo when given with other drugs to treat participants with HER2-positive breast cancer. A placebo is a pill that looks the same as tucatinib but has no medicine in it. This study will also test what side effects happen when participants take this combination of drugs. A side effect is anything a drug does to the body besides treating your disease.
Participants will have cancer that has spread in the body near where it started (locally advanced) and cannot be removed (unresectable) or has spread through the body (metastatic).
In this study, all participants will get either tucatinib or placebo. Participants will be assigned randomly to a group. This is a blinded study, so patients and their doctors will not know which group a participant is in.
All participants will also get trastuzumab and pertuzumab. These are 2 drugs used to treat this type of cancer.
- Detailed Description
Control arm: Placebo given orally twice daily plus trastuzumab and pertuzumab every 21 days
Experimental arm: Tucatinib 300 mg given orally twice daily plus trastuzumab and pertuzumab every 21 days
Trastuzumab and pertuzumab will be administered as follows:
• Trastuzumab will be given intravenously (IV) at a dose of 6 mg/kg or subcutaneously (SC) at a fixed dose of 600 mg, once every 21 days.
AND
* Pertuzumab will be given IV at 420 mg every 21 days. OR
* Fixed dose combination of 600 mg pertuzumab, 600 mg trastuzumab, and 20,000 units hyaluronidase will be given SC, once every 21 days, in lieu of trastuzumab and pertuzumab individually.
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 650
-
Centrally confirmed HER2+ breast carcinoma according to the 2018 American Society of Clinical Oncologists (ASCO) College of American Pathologists (CAP) guidelines prior to randomization (defined as a 3+ score on immunohistochemistry (IHC) and/or 2+ IHC and concurrent positive by ISH).
-
Have unresectable locally advanced or metastatic disease.
- If recurrent (after [neo]adjuvant therapy), must be at least 6 month treatment free from any trastuzumab and pertuzumab received in the early breast cancer setting for advanced HER2+ disease.
-
Have received 4-8 cycles of pre-study induction therapy including only trastuzumab, pertuzumab, and taxane as first-line of therapy for the treatment of advanced breast cancer prior to study enrollment. Participants are eligible provided they are without evidence of disease progression following completion of induction therapy.
-
Known hormone receptor status (per local guidelines; may be hormone receptor positive [HR+] or negative [HR-])
-
Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1
-
CNS Inclusion - Based on screening contrast-enhanced brain magnetic resonance imaging (MRI), participants may have any of the following:
-
No evidence of brain metastases
-
Untreated brain metastases which are asymptomatic not needing immediate local treatment and, if identified on prior brain imaging, without evidence of progression since starting first-line induction therapy with trastuzumab, pertuzumab, and taxane
-
Previously treated brain metastases which are asymptomatic
- Brain metastases previously treated with local therapy must not have progressed since treatment
-
-
Prior treatment with any tyrosine kinase inhibitor targeting HER2 and/or epidermal growth factor receptor (EGFR) including pyrotinib, lapatinib, tucatinib, neratinib, and afatinib (except neratinib if given in extended adjuvant setting and ≥ 12 months have elapsed since last neratinib dose prior to start of study drug)
-
Unable to undergo contrast-enhanced MRI of the brain
-
CNS Exclusion - Based on screening brain MRI and clinical assessment
- Symptomatic brain metastasis after CNS-directed local therapy
- Progression of brain metastases since starting first line trastuzumab, pertuzumab, and taxane
- Ongoing use of systemic corticosteroids at a total daily dose of >2 mg of dexamethasone (or equivalent)
- Any untreated brain lesion in an anatomic site which may pose risk to participant
- Known or suspected leptomeningeal disease (LMD)
- Poorly controlled (>1/week) seizures, or other persistent neurologic symptoms
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Placebo + trastuzumab + pertuzumab Pertuzumab Placebo + trastuzumab + pertuzumab Tucatinib + trastuzumab + pertuzumab Tucatinib Tucatinib + trastuzumab + pertuzumab Tucatinib + trastuzumab + pertuzumab Trastuzumab Tucatinib + trastuzumab + pertuzumab Placebo + trastuzumab + pertuzumab Placebo Placebo + trastuzumab + pertuzumab Tucatinib + trastuzumab + pertuzumab Pertuzumab Tucatinib + trastuzumab + pertuzumab Placebo + trastuzumab + pertuzumab Trastuzumab Placebo + trastuzumab + pertuzumab
- Primary Outcome Measures
Name Time Method Progression-free survival (PFS) by investigator assessment per Response Evaluation Criteria in Solid Tumors (RECIST) v1.1 Up to approximately 3 years The time from the date of randomization to the investigator assessment of disease progression according to RECIST v1.1 or death from any cause
- Secondary Outcome Measures
Name Time Method PFS by blinded independent central review (BICR) per RECIST v1.1 Up to approximately 3 years The time from the date of randomization to the documented disease progression assessed by BICR according to RECIST v1.1 or death from any cause
Time to deterioration of health-related quality of life (HRQoL) Up to approximately 3 years Will be measured based on patient reported outcomes (PROs) according to the European Organization for Research and Treatment of Cancer quality of life questionnaire (EORTC QLQ C30).
Central nervous system (CNS) PFS Up to approximately 3 years The time from randomization to investigator assessed disease progression in brain (RECIST v1.1), or death from any cause
Incidence of adverse events (AEs) Through 30 days after last study treatment, approximately 18 months Any untoward medical occurrence in a clinical investigational participant administered a medicinal product and which does not necessarily have a causal relationship with this treatment.
Incidence of laboratory abnormalities Through 30 days after last study treatment, approximately 18 months To be summarized using descriptive statistics.
Incidence of tucatinib dose alterations Through 30 days after last study treatment, approximately 18 months To be summarized using descriptive statistics.
Incidence of trastuzumab dose alterations Through 30 days after last study treatment, approximately 18 months To be summarized using descriptive statistics.
Incidence of pertuzumab dose alterations Through 30 days after last study treatment, approximately 18 months To be summarized using descriptive statistics.
Maximum concentration (Cmax) Through 30 days after last study treatment, approximately 18 months To be summarized using descriptive statistics.
Trough concentration (Ctrough) Through 30 days after last study treatment, approximately 18 months To be summarized using descriptive statistics.
Overall survival (OS) Up to approximately 5 years The time from randomization to death from any cause.
Trial Locations
- Locations (380)
James Lind Centro De Investigacion Del Cancer
🇨🇱Temuco, Chile
The Second Hospital of Anhui Medical University
🇨🇳Hefei City, Anhui, China
Universitatsklinikum Wurzburg Apotheke
🇩🇪Wurzburg, Germany
Mayo Clinic Hospital
🇺🇸Phoenix, Arizona, United States
Mayo Clinic
🇺🇸Scottsdale, Arizona, United States
CARTI Cancer Center,Central Arkansas Radiation Therapy Institute
🇺🇸Little Rock, Arkansas, United States
CARTI Cancer Center
🇺🇸Little Rock, Arkansas, United States
UCLA Hematology/Oncology - Beverly Hills
🇺🇸Beverly Hills, California, United States
UCLA Hematology/Oncology - Burbank
🇺🇸Burbank, California, United States
UCSD Medical Center - Encinitas
🇺🇸Encinitas, California, United States
Koman Family Outpatient Pavilion
🇺🇸La Jolla, California, United States
Sulpizio Cardiovascular Center at UC San Diego Health
🇺🇸La Jolla, California, United States
UC San Diego Medical Center - La Jolla (Jacobs Medical Center / Thornton Pavilion)
🇺🇸La Jolla, California, United States
UCSD Perlman Medical Offices
🇺🇸La Jolla, California, United States
UC San Diego Moores Cancer Center
🇺🇸La Jolla, California, United States
UCLA Hematology/Oncology - Laguna Hills
🇺🇸Laguna Hills, California, United States
UCLA Hematology/Oncology
🇺🇸Los Angeles, California, United States
UC San Diego Medical Center - Hillcrest
🇺🇸San Diego, California, United States
UCLA Hematology/Oncology - San Luis Obispo
🇺🇸San Luis Obispo, California, United States
UCLA Hematology/Oncology- Santa Barbara
🇺🇸Santa Barbara, California, United States
UCLA Hematology/Oncology - Santa Monica
🇺🇸Santa Monica, California, United States
UCLA Hematology/Oncology Parkside
🇺🇸Santa Monica, California, United States
Clinical And Translational Research Center
🇺🇸Torrance, California, United States
Investigational Drug Service
🇺🇸Torrance, California, United States
Lundquist Institute/Harbor-UCLA
🇺🇸Torrance, California, United States
The Lundquist Institute for Biomedical Innovation at H arbor-UCLA M edical Center
🇺🇸Torrance, California, United States
Harbor-UCLA Medical Center
🇺🇸Torrance, California, United States
UCLA Hematology/Oncology - Santa Clarita
🇺🇸Valencia, California, United States
UCSD Medical Center - Vista
🇺🇸Vista, California, United States
UCLA Hematology/Oncology- Westlake
🇺🇸Westlake Village, California, United States
AdventHealth Altamonte Infusion Center
🇺🇸Altamonte Springs, Florida, United States
AdventHealth Medical Group Altamonte(second location)
🇺🇸Altamonte Springs, Florida, United States
AdventHealth Medical Group Altamonte
🇺🇸Altamonte Springs, Florida, United States
Mayo Clinic Florida
🇺🇸Jacksonville, Florida, United States
AdventHealth Cancer Institute
🇺🇸Orlando, Florida, United States
AdventHealth Medical Group Orlando
🇺🇸Orlando, Florida, United States
AdventHealth Orlando Infusion Center
🇺🇸Orlando, Florida, United States
Emory University Hospital Midtown
🇺🇸Atlanta, Georgia, United States
Winship Cancer Institute
🇺🇸Atlanta, Georgia, United States
Emory Saint Joseph's Hospital
🇺🇸Atlanta, Georgia, United States
University of Illinois Hospital and Health Systems (Outpatient Cancer Center)
🇺🇸Chicago, Illinois, United States
University of Illinois Hospital and Health Systems
🇺🇸Chicago, Illinois, United States
Norton Cancer Institute - Downtown
🇺🇸Louisville, Kentucky, United States
Norton Hospital
🇺🇸Louisville, Kentucky, United States
Brownsboro Diagnostic Center
🇺🇸Louisville, Kentucky, United States
Norton Cancer Institute, St Matthews Campus
🇺🇸Louisville, Kentucky, United States
Norton Cancer Institute, St. Matthews Campus
🇺🇸Louisville, Kentucky, United States
Norton Diagnostic Center - Dupont
🇺🇸Louisville, Kentucky, United States
Norton Women's & Children's Hospital
🇺🇸Louisville, Kentucky, United States
Norton Brownsboro Hospital
🇺🇸Louisville, Kentucky, United States
Norton Cancer Institute, Brownsboro Hospital Campus
🇺🇸Louisville, Kentucky, United States
Norton Cancer Institute
🇺🇸Louisville, Kentucky, United States
Norton Diagnostic Center - Fern Creek
🇺🇸Louisville, Kentucky, United States
Mercy Medical Center
🇺🇸Baltimore, Maryland, United States
Mayo Clinic Rochester
🇺🇸Rochester, Minnesota, United States
Saint Luke's Cancer Institute.
🇺🇸Kansas City, Missouri, United States
Oncology Hematology West PC dba Nebraska Cancer Specialists
🇺🇸Papillion, Nebraska, United States
Oncology Hematology West, PC dba Nebraska Cancer Specialists - Grand Island
🇺🇸Grand Island, Nebraska, United States
Oncology Hematology West, P.C.
🇺🇸Omaha, Nebraska, United States
RWJBarnabas Health- Jersey City Medical Center
🇺🇸Jersey City, New Jersey, United States
RWJBarnabas Health- Monmouth Medical Center-Southern Campus
🇺🇸Lakewood, New Jersey, United States
RWJBarnabas Health- Cooperman Barnabas Medical Center
🇺🇸Livingston, New Jersey, United States
RWJBarnabas Health- Monmouth Medical Center
🇺🇸Long Branch, New Jersey, United States
Newark Beth Israel Medical Center
🇺🇸Newark, New Jersey, United States
RWJBarnabas Health-Robert Wood Johnson University Hospital, Somerset
🇺🇸Somerville, New Jersey, United States
Steeplechase Cancer Center
🇺🇸Somerville, New Jersey, United States
RWJBarnabas Health - Community Medical Center
🇺🇸Toms River, New Jersey, United States
Satellite Infusion Center-Monmouth Medical Center Vantage Point Infusion Center
🇺🇸West Long Branch, New Jersey, United States
Montefiore-Einstein Center for Cancer Care
🇺🇸Bronx, New York, United States
Cleveland Clinic
🇺🇸Cleveland, Ohio, United States
Cleveland Clinic Cancer Center - Strongsville
🇺🇸Strongsville, Ohio, United States
Tennessee Oncology, PLLC
🇺🇸Smyrna, Tennessee, United States
University of Washington Medical Center
🇺🇸Seattle, Washington, United States
Froedtert Hospital/Medical College of Wisconsin
🇺🇸Milwaukee, Wisconsin, United States
Chris O'Brien Lifehouse
🇦🇺Camperdown, New South Wales, Australia
Macquarie University Clinical Trials Unit.
🇦🇺Macquarie University, New South Wales, Australia
Macquarie University Hospital
🇦🇺Macquarie University, New South Wales, Australia
Baxter Healthcare Pty Limited
🇦🇺Old Tonggabbie, New South Wales, Australia
Pharmacy Macquarie University Hospital
🇦🇺Sydney, New South Wales, Australia
Westmead Hospital
🇦🇺Sydney, New South Wales, Australia
Western Sydney Local Health District (WSLHD), Westmead Hospital
🇦🇺Westmead, New South Wales, Australia
Cancer Research SA
🇦🇺Adelaide, South Australia, Australia
HPS Pharmacies -Adelaide (South Tee) (lnvestigational Product storage and dispensing)
🇦🇺Adelaide, South Australia, Australia
St Andrews Medical Centre
🇦🇺Adelaide, South Australia, Australia
Flinders Medical Centre
🇦🇺Bedford Park, South Australia, Australia
Box Hill Hospital
🇦🇺Box Hill, Victoria, Australia
Austin Health
🇦🇺Heidelberg, Victoria, Australia
St John of God Subiaco Hospital Clinical Trials Unit Bendat Family Comprehensive Cancer Centre
🇦🇺Subiaco, Washington, Australia
St John of God Subiaco Hospital
🇦🇺Subiaco, Western Australia, Australia
Ordination Priv.-Doz. Dr. Michael Hubalek
🇦🇹Schwaz, Other, Austria
Anstaltsapotheke des Landeskrankenhauses
🇦🇹Graz, Austria
Medizinische Universitat Graz
🇦🇹Graz, Austria
Ordensklinikum Linz GmbH Barmherzige Schwestern
🇦🇹Linz, Austria
Marien Apotheke Schwaz
🇦🇹Schwaz, Austria
Anstaltsapotheke des Allgemeinen Krankenhauses der Stadt Wien
🇦🇹Wien, Austria
Medizinische Universitat Wien Universitatsklinik Fur Frauenheilkunde
🇦🇹Wien, Austria
Institut Jules Bordet
🇧🇪Anderlecht, Brussels, Belgium
Universitair Ziekenhuis Brussel
🇧🇪Bruxelles-Capitale, Oost-vlaanderen, Belgium
Clinique Saint Pierre
🇧🇪Ottignies, Walloon Brabant, Belgium
Jules Bordet lnstituut
🇧🇪Anderlecht, Belgium
Cliniques Universitaires Saint-Luc
🇧🇪Brussels, Belgium
UCL Saint-Luc
🇧🇪Brussels, Belgium
Universitair Ziekenhuis Brussel (UZ Brussel)
🇧🇪Brussel, Belgium
Clinique St Pierre
🇧🇪Ottignies, Belgium
Centro Regional Integrado de Oncologia
🇧🇷Fortaleza, Ceara, Brazil
CRIO - Centro Regional lntegrado de Oncologia
🇧🇷Fortaleza, Ceara, Brazil
Hospital Araujo Jorge
🇧🇷Goiania, Goias, Brazil
Clinica de Pesquisas e Centro de Estudos em Oncologia Ginecologica e Mamaria Ltda.
🇧🇷Bela Vista, Other, Brazil
Hospital Araujo Jorge - Associacao de Combate ao Cancer em Goias
🇧🇷Goiania, Other, Brazil
Centro Gaucho Integrado de Oncologia, Hematologia, Ensino e Pesquisa
🇧🇷Porto Alegre, Other, Brazil
Hospital Do Cancer De Londrina
🇧🇷Londrina, Parana, Brazil
Liga Norte-Rio Grandense Contra o Cancer
🇧🇷Natal, RIO Grande DO Norte, Brazil
Liga Norte-Rio-Grandense Contra o Cancer
🇧🇷Natal, RIO Grande DO Norte, Brazil
Irmandade da Santa Casa de Misericordia de Porto Alegre
🇧🇷Porto Alegre, RIO Grande DO SUL, Brazil
Hospital de Clinicas de Porto Alegre
🇧🇷Porto Alegre, RIO Grande DO SUL, Brazil
Centro Gaucho Integrado de Oncologia, Hematologia, Ensino e Pesquisa - Hospital do Cancer Mae de Deu
🇧🇷Porto Alegre, RIO Grande DO SUL, Brazil
Hospital de Cancer de Barretos - Fundacao Pio XII
🇧🇷Barretos, SAO Paulo, Brazil
Fundacao Pio XII, Hospital do Amor de Barretos
🇧🇷Barretos, SAO Paulo, Brazil
Fundacao Dr Amaral Carvalho
🇧🇷Jau, SAO Paulo, Brazil
Fundacao Doutor Amaral Carvalho
🇧🇷Jaú, SAO Paulo, Brazil
CEPHO- Centro de Estudos e Pesquisas de Hematologia e Oncologia
🇧🇷Santo Andre, SAO Paulo, Brazil
CEPHO - Centro de Estudos e Pesquisas de Hematologia e Oncologia
🇧🇷Santo Andre, SAO Paulo, Brazil
Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto
🇧🇷Sao Jose Rio Preto, SAO Paulo, Brazil
Irmandade da Santa Casa de Misericordia de Porto Alegre centro Multidisciplinar de pesquisa clinica
🇧🇷Porto Alegre/RS, Brazil
Faculdade Regional de Medicina de Sao Jose do Rio Preto
🇧🇷Sao Jose do Rio Preto, Brazil
ICESP- Instituto do Cancer do Estado de Sao Paulo Octavio Frias de Oliveira
🇧🇷Sao Paulo, Brazil
Fundacao Antonio Prudente (AC Camargo Cancer Center)
🇧🇷Sao Paulo, Brazil
Sao Camilo Oncologia
🇧🇷Sao Paulo, Brazil
Clinica de Pesquisas e Centro de Estudos em Oncologia Ginecologica e Mamária Ltda.
🇧🇷Sao Paulo, Brazil
A.C. Camargo Câncer Center
🇧🇷São Paulo/SP, Brazil
ICESP - Instituto do Cancer do Estado de Sao Paulo Octavio Frias de Oliveira
🇧🇷São Paulo, Brazil
Cross Cancer Institute
🇨🇦Edmonton, Alberta, Canada
BC Cancer Agency
🇨🇦Kelowna, British Columbia, Canada
Ottawa Hospital Cancer Centre
🇨🇦Ottawa, Ontario, Canada
The Ottawa Hospital Cancer Centre
🇨🇦Ottawa, Ontario, Canada
Sunnybrook Research Institute
🇨🇦Toronto, Ontario, Canada
Mount Sinai Hospital - Toronto
🇨🇦Toronto, Ontario, Canada
Centre integre universitaire de sante et de services sociaux du Saguenay-Lac-Saint-Jean
🇨🇦Chicoutimi, Quebec, Canada
Centre Hospitalier de l'Universite de Motreal (CHUM)
🇨🇦Montreal, Quebec, Canada
Jewish General Hospital
🇨🇦Montreal, Quebec, Canada
Sociedad de Investigaciones Medicas Limitada
🇨🇱Temuco, Cautin, Chile
Centro de Investigacion Clínica Bradford Hill
🇨🇱Recoleta, Santiago, Chile
Oncocentro Apys
🇨🇱Viña del Mar, Valparaíso, Chile
Centro de Investigacion Clinica Bradford Hill
🇨🇱Santiago, Chile
Clinica Universidad Catolica del Maule
🇨🇱Talca, Chile
Guangdong Provincial People's Hospital
🇨🇳Guangzhou, Guangdong, China
Meizhou People's Hospital - Guangdong Province
🇨🇳Meizhou, Guangdong, China
Meizhou People's Hospital
🇨🇳Meizhou, Guangdong, China
Liuzhou People's Hospital
🇨🇳Liuzhou, Guangxi, China
Guangxi Medical University Affiliated Tumor Hospital
🇨🇳Nanning, China
The First Affiliated Hospital of Guangxi Medical University
🇨🇳Nanning, Guangxi, China
The first Affiliated Hospital of Hainan Medical University
🇨🇳Haikou, Hainan, China
Affiliated Hospital of Hebei University
🇨🇳Baoding City, Hebei, China
Henan Cancer Hospital
🇨🇳Zhengzhou City, Henan, China
Union Hospital affiliated to Tongji Medical College of Huazhong University of Science and Technology
🇨🇳Wuhan City, Hubei, China
Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology
🇨🇳Wuhan, Hubei, China
Hubei Cancer Hospital
🇨🇳Wuhan, Hubei, China
The Second Xiangya Hospital of Central South University
🇨🇳Changsha, Hunan, China
Jiangsu Province Hospital
🇨🇳Nanjing City, Jiangsu, China
The Second Affiliated Hospital of Nanchang University
🇨🇳Nanchang, Jiangxi, China
The First Hospital of Jilin University
🇨🇳Changchun, Jilin, China
The First Hospital of China Medical University
🇨🇳Shenyang City, Liaoning, China
Liaoning Cancer Hospital & Insitute
🇨🇳Shenyang City, Liaoning, China
Liaoning Cancer Hospital and Institute
🇨🇳Shenyang, Liaoning, China
Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine
🇨🇳Hangzhou, Other, China
Ruijin Hospital of Shanghai Jiaotong University School of Medicine
🇨🇳Shanghai, Other, China
Shaanxi Provincial People's Hospital
🇨🇳Xi'an City, Shaanxi, China
The First Affiliated Hospital of Xi'an Jiaotong University
🇨🇳Xi'an, Shaanxi, China
Jinan Central Hospital
🇨🇳Jinan, Shandong, China
Linyi Cancer Hospital
🇨🇳Linyi City, Shandong, China
Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
🇨🇳Hangzhou City, Zhejiang, China
Zhejiang Cancer Hospital
🇨🇳Hangzhou City, Zhejiang, China
The Second Affiliated Hospital of Zhejiang University School of Medicine
🇨🇳Binjiang District, China
Beijing Hospital
🇨🇳Beijing, China
The First Bethune Hospital of Jilin University
🇨🇳Changchun, China
Nanjing Medical University (NMU) - Jiangsu Province Hospital
🇨🇳Nanjing, China
The People's Hospital of Guangxi Zhuang Autonomous Region
🇨🇳Nanning, China
Fudan University Shanghai Cancer Center
🇨🇳Shanghai, China
Ruijin Hospital, Shanghai Jiaotong University School of Medicine
🇨🇳Shanghai, China
Tianjin Medical University Cancer Institute & Hospital
🇨🇳Tianjin City, China
Lekarna Vseobecne fakultni nemocnice v Praze
🇨🇿Praha, Praha 2, Czechia
Masarykuv Onkologicky Ustav
🇨🇿Brno, Czechia
Ustavni lekarna Masarykuv onkologicky ustav
🇨🇿Brno, Czechia
Vseobecna fakultni nemocnice v Praze
🇨🇿Praha 2, Czechia
Lekarna FTN
🇨🇿Praha 4 - Krc, Czechia
Fakultni Thomayerova nemocnice Onkologicka klinika 1. LF UK a FTN
🇨🇿Praha 4 - Krc, Czechia
Fakultni nemocnice v Motole Onkologicka klinika 2. LF UK a FN Motol
🇨🇿Praha 5 - Motol, Czechia
Tampere University Hospital pharmacy
🇫🇮Tampere, Finland
Tampere University Hospital, FONK/RSYO
🇫🇮Tampere, Finland
Tampere University Hospital
🇫🇮Tampere, Finland
Centre Henri Becquerel / Centre Regional de Lutte Contre le Cancer
🇫🇷Rouen, Bretagne, France
Institut Bergonie
🇫🇷Bordeaux, Cedex, France
Centre de Cancérologie du Grand Montpellier
🇫🇷Montpellier, Languedoc-roussillon, France
Institut de Cancerologie de lOuest-Saint Herblain
🇫🇷Saint Herblain, Loire-atlantique, France
Centre de Lutte contre le Cancer (CLCC) - Centre Antoine Lacassagne
🇫🇷Nice Cedex 2, Lyon, France
Institut de Cancerologie de lOuest - Site Rene Gauducheau
🇫🇷Saint Herblain cedex, Mainet-et-loire, France
Centre Hospitalier Regional et Universitaire de Besancon - Hopital Jean-Minjoz
🇫🇷Besancon Cedex, Other, France
Center Georges Francois Leclerc
🇫🇷Dijon, Other, France
Institute Curie - Centre de Lutte Contre le Cancer - Centre Rene Huguenin
🇫🇷Saint-Cloude, Other, France
Centre de Lutte contre le Cancer - Francois Baclesse
🇫🇷Caen Cedex 5, Provence Alpes COTE D-azur, France
Institut Sainte-Catherine.
🇫🇷Avignon Cedex 9, France
Sainte Catherine Institut du Cancer Avignon Provence
🇫🇷Avignon, France
CHU Besancon - Pole Pharmaceutique - Unite essais cliniques
🇫🇷Besancon, France
CHU Besancon
🇫🇷Besangon, France
Centre Hospitalier Universitaire Hopital Avicenne
🇫🇷Bobigny, France
Hopital Avicenne
🇫🇷Bobigny, France
Centre de Lutte contre le Cancer - François Baclesse
🇫🇷Caen Cedex 5, France
CENTRE FRANCOIS BACLESSE - Service lmagerie medicale
🇫🇷Caen, France
Centre Jean Perrin
🇫🇷Clermont Ferrand, France
Centre Jean Perrin - Pharmacy
🇫🇷Clermont-Ferrand, France
CARIO - Centre Armoricain De Radiothérapie, D'imagerie Médicale Et D'oncologie
🇫🇷Cotes d'Armor, France
Center Georges-Francois Leclerc
🇫🇷Dijon, France
Centre de Lutte contre le Cancer (CLCC) - Centre Oscar Lambret
🇫🇷Lille, France
Centre Oscar Lambret
🇫🇷Lille, France
Center Leon Berard
🇫🇷Lyon, France
Institut Régional du Cancer de Montpellier
🇫🇷Montpellier Cedex 5, France
Institut Regional du Cancer de Montpellier Service lmagerie medicale
🇫🇷Montpellier, France
lnstitut Regional du Cancer de Montpellier- Service Pharmacie
🇫🇷Montpellier, France
Institut Regional du Cancer de Montpellier
🇫🇷Montpellier, France
Centre Antoine Lacassagne
🇫🇷Nice cedex 2, France
Pharmacy :Centre Antoine Lacassagne
🇫🇷Nice, France
Institut Curie - site de Paris - Pharmacy
🇫🇷Paris, France
Institut Curie - site de Paris, Unitéd Investigation Clinique
🇫🇷Paris, France
Hopitaux Civils de Lyon
🇫🇷Pierre Benite, France
Hospices Civils de Lyon
🇫🇷Pierre Benite, France
"CARIO - Centre Armoricain de Radiotherapie lmagerie medicate et d'Oncologie -Hopital Prive des
🇫🇷Plerin, France
Centre Eugene Marquis Pharmacie - Essais Cliniques
🇫🇷Rennes, France
Centre Eugene Marquis
🇫🇷Rennes, France
Centre Henri Becquerel
🇫🇷Rouen, France
Institut Curie - site St-Cloud
🇫🇷Saint-Cloud, France
Institut de Cancerologie Strasbourg Europe
🇫🇷Strasbourg, France
Centre Paul Strauss Pharmacie - Essais cliniques
🇫🇷Strasbourg, France
Institut Curie
🇫🇷Saint-Cloud, Île-de-france, France
Universitaetsklinikum Hamburg-Eppendorf (UKE)
🇩🇪Hamburg, North Rhine-westphalia, Germany
Pharmacy:Fortuna Herstellung GmbH
🇩🇪Mannheim, Other, Germany
"Universitatsklinikum Augsburg Klinik fur Frauenheilkunde und Geburtshilfe"
🇩🇪Augsburg, Germany
Charite Universtitatsmedizin Berlin Klinik fur Gynakologie mit Brustzentrum
🇩🇪Berlin, Germany
"Pharmacy: Universitatsklinikum Hamburg-Eppendorf Apotheke (Gebaude N19)"
🇩🇪Hamburg, Germany
Universitätsmedizin Mannheim Universitätsfrauenklinik
🇩🇪Manheim, Germany
Klinikum Rechts der Isar der Technischen Universitaet Muenchen
🇩🇪Muenchen, Germany
University Hospital Muenster Senology
🇩🇪Munster, Germany
Universitatsklinikum Ulm Klinik fur Frauenheilkunde und Geburtshilfe
🇩🇪Ulm, Germany
Apotheke des Universitatsklinikums Ulm
🇩🇪Ulm, Germany
Universitatsklinikum Wurzburg Frauenklinik und Poliklinik
🇩🇪Wurzburg, Germany
Universitatsklinikum Wurzburg, Comprehensive Cancer Center - Mainfranken (CCCMF)
🇩🇪Wurzburg, Germany
General Hospital of Athens "Alexandra" Clinical Therapeutics Department, Hematology/Oncology Unit
🇬🇷Athens, Attica, Greece
University Hospital of Larissa
🇬🇷Larissa, Other, Greece
University General Hospital of Patras, Oncology Department, Internal Medicine Clinic
🇬🇷Patra, Peloponnese, Greece
Alexandra General Hospital of Athens
🇬🇷Athens, Greece
University General Hospital of Larissa, Oncology Clinic
🇬🇷Larissa, Greece
IASO
🇬🇷Maroussi, Greece
Metaxa Anticancer Hospital of Piraeus
🇬🇷Pireaus, Greece
Azienda Ospedaliera Universitaria (AOU) Federico II
🇮🇹Napoli, Campania, Italy
Azienda Ospedaliera Universitaria Federico II
🇮🇹Napoli, Campania, Italy
Istituto Nazionale Tumori IRCCS Fondazione G. Pascale
🇮🇹Napoli, Campania, Italy
lstituto Nazionale Tumori IRCCS - Fondazione Pascale U.O.C. Oncologia Medica Senologica
🇮🇹Napoli, Campania, Italy
Farmacia centrale
🇮🇹Genova, Liguria, Italy
IRCCS Ospedale Policlinico, San Martino
🇮🇹Genova, Liguria, Italy
Istituto Clinico Humanitas-Humanitas Cancer Center
🇮🇹Rozzano (Milano), Lombardia, Italy
ASST Monza Ospedale San Gerardo Centro Ricerca di Fase 1
🇮🇹Monza (MB), Lombardy, Italy
Azienda Ospedaliero Universitaria delle Marche SOD Clinica Oncologica
🇮🇹Torrette, Marche, Italy
Divisione di Farmacia Istituto Europeo di Oncologia
🇮🇹Milano, Milan, Italy
Istituto Europeo di Oncologia
🇮🇹Milano, MI, Italy
U.O. Farmacia Asst Monza
🇮🇹Monza, Monza AND Brianza, Italy
Humanitas lstituto Clinico Catanese
🇮🇹Catania (CT), Sicily, Italy
Divisione Oncologia Medica, Ospedale di Trento - Presidio Ospedaliero (PO) Santa Chiara
🇮🇹Trento, Trentino, Italy
SOC Farmacia, Ospedale di Trento - Presidio Ospedaliero (PO)
🇮🇹Trento, Trentino, Italy
Oncologia Medica Azienda Usl Toscana Nord Ovest - Ospedali Riuniti di Livor
🇮🇹Livorno, Tuscany, Italy
S.O.C. Oncologia Medica - Nuovo Ospedale di Prato Santo Stefano
🇮🇹Prato, Tuscany, Italy
Azienda Ospedaliero-Universitaria di Bologna Policlinico S. Orsola-Malpighi
🇮🇹Bologna, Italy
SSD Oncologia Medica Addarii - Zamagni, Policlinico Sant'Orsola - Malpighi
🇮🇹Bologna, Italy
Azienda Ospedaliera Universitaria San Martino
🇮🇹Genova, Italy
UOC Farmaceutica Ospedaliera Azienda Usl Toscana Nord Ovest - Ospedali Riuniti di Livorno
🇮🇹Livorno, Italy
Divisione di Senologia Medica; Istituto Europeo di Oncologia
🇮🇹Milano, Italy
Farmacia Istituto Clinico Humanitas
🇮🇹Milan, Italy
UOC di Oncologia Medica, Azienda Ospedaliero Universitaria (AOU) di Parma
🇮🇹Parma, Italy
Istituti Clinici Scientifici Maugeri IRCCS
🇮🇹Pavia, Italy
Tesshokai Kameda General Hospital
🇯🇵Kamogawa-shi, Chiba-ken, Japan
Medical Corporation Tesshokai Kameda Medical Center
🇯🇵Kamogawa, Chiba, Japan
National Cancer Center Hospital East
🇯🇵Kashiwa-Shi, Chiba, Japan
Shikoku Cancer Center
🇯🇵Matsuyama-shi, Ehime-ken, Japan
NHO Shikoku Cancer Center
🇯🇵Matsuyama, Ehime, Japan
National Hospital Organization Kyushu Cancer Center
🇯🇵Fukuoka-city, Fukuoka, Japan
Fukushima Medical University Hospital
🇯🇵Fukushima-shi, Fukushima, Japan
National Hospital Organization Hokkaido Cancer Center
🇯🇵Sapporo, Hokkaido, Japan
Ishikawa Prefectural Central Hospital
🇯🇵Kanazawa-shi, Ishikawa, Japan
Kanagawa Cancer Center
🇯🇵Yokohama, Kanagawa, Japan
University of Tsukuba Hospital
🇯🇵Tsukuba-shi, Lbaraki-ken, Japan
Naha Nishi Clinic
🇯🇵Naha-shi, Okinawa-ken, Japan
Medical Corporation Nahanishikai Nahanishi Clinic
🇯🇵Naha-shi, Okinawa, Japan
Kindai University Hospital
🇯🇵Osakasayama-shi, Osaka-fu, Japan
St. Luke's International Hospital
🇯🇵Chuo-ku, Tokyo-to, Japan
National Cancer Center Hospital
🇯🇵Chuo-ku, Tokyo, Japan
St. Luke's International Hospital.
🇯🇵Chuo-ku, Tokyo, Japan
Toranomon Hospital
🇯🇵Minato-ku, Tokyo, Japan
Showa University Hospital
🇯🇵Shinagawa-ku, Tokyo, Japan
Chungbuk Nationl University Hospital
🇰🇷Cheongju-si, Chungcheongbuk-do, Korea, Republic of
Severance Hospital, Yonsei University Health System
🇰🇷Seoul, Korea, Republic of
Yonsei University Wonju Severance Christian Hospital
🇰🇷Wonju-si, Gangwon-do, Korea, Republic of
National Cancer Center
🇰🇷Goyang-Si, Gyeonggi-do, Korea, Republic of
Seoul National University Bundang Hospital
🇰🇷Seongnam-si, Gyeonggi-do, Korea, Republic of
The Catholic University of Korea, St. Vincent's Hospital
🇰🇷Suwon-si, Gyeonggi-do, Korea, Republic of
Ajou University Hospital
🇰🇷Suwon-si, Gyeonggi-do, Korea, Republic of
St. Vincent's Hospital, The Catholic University of Korea
🇰🇷Suwon-si, Gyeonggido [kyonggi-do], Korea, Republic of
Dong-A University Hospital
🇰🇷Busan, Korea, Republic of
Gachon University Gil Medical Center
🇰🇷Incheon, Korea, Republic of
Korea University Anam Hospital
🇰🇷Seoul, Korea, Republic of
Seoul National University Hospital
🇰🇷Seoul, Korea, Republic of
Severance Hospital Yonsei University Health System
🇰🇷Seoul, Korea, Republic of
Asan Medical Center
🇰🇷Seoul, Korea, Republic of
Gangnam Severance Hospital, Yonsei University Health System
🇰🇷Seoul, Korea, Republic of
Gangnam Severance Hospital
🇰🇷Seoul, Korea, Republic of
Seoul Saint Mary's Hospital
🇰🇷Seoul, Korea, Republic of
The Catholic University of Korea, Seoul St. Mary's Hospital
🇰🇷Seoul, Korea, Republic of
Ewha Womans University Mokdong Hospital
🇰🇷Seoul, Korea, Republic of
VieCuri Medisch Centrum
🇳🇱Venlo, Other, Netherlands
Albert Schweitzer Hospital
🇳🇱Doedrecht, Zuid-holland, Netherlands
Albert Schweitzer Ziekenhuis
🇳🇱Dordrecht, Netherlands
St. Antonius Hospital
🇳🇱Utrecht, Netherlands
VieCuri Medsich Centrum
🇳🇱Venlo, Netherlands
Uniwersyteckie Centrum Kliniczne
🇵🇱Gdansk, Poland
Wojewodzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im. M. Kopernika w Lodzi
🇵🇱Lodz, Poland
SP ZOZ Opolskie Centrum Onkologii im. Prof. Tadeusza Koszarowskiego w Opolu
🇵🇱Opole, Poland
Narodowy lnstytut Onkologii im. Marii Sklodowskiej-Curie-Panstwowy lnstytut Badawczy
🇵🇱Gliwice, Śląskie, Poland
Centro Clinico Academico Braga Hospital de Braga
🇵🇹Braga, Portugal
Hospital de Braga
🇵🇹Braga, Portugal
Instituto Portugues de Oncologia de Coimbra Francisco Gentil, EPE (IPO, Coimbra)
🇵🇹Coimbra, Portugal
Fundacao Champalimaud
🇵🇹Lisboa, Portugal
Hospital CUF Descobertas
🇵🇹Lisboa, Portugal
Champalimaud Clinical Center
🇵🇹Lisbon, Portugal
Hospital General Universitario Alicante
🇪🇸Alicante, Comunidad Valenciana, Spain
Hospital Universitario Son Espases
🇪🇸Palma de Mallorca, Islas Baleares, Spain
Hospital Universitario Virgen De La Arrixaca
🇪🇸EI Palmar, Murcia, Spain
Hospital Universitario de Canarias
🇪🇸La Laguna Tenerife, Santa CRUZ DE Tenerife, Spain
Hospital Universitari Vall d'Hebron
🇪🇸Barcelona, Spain
Hospital de la Santa Creu i Sant Pau
🇪🇸Barcelona, Spain
Hospital Universitario de Basurto
🇪🇸Bilbao, Spain
Hospital San Pedro de Alcantara
🇪🇸Caceres, Spain
Institut Catala d'Oncologia Girona - ICO Girona
🇪🇸Girona, Spain
Hospital Universitario Virgen de las Nieves
🇪🇸Granada, Spain
Hospital Universitari Arnau de Vilanova
🇪🇸Lleida, Spain
Hospital General Universitario Gregorio Maranon
🇪🇸Madrid, Spain
Hospital Universitario Ramon y Cajal
🇪🇸Madrid, Spain
Hospital Universitario Virgen de la Victoria
🇪🇸Malaga, Spain
Hospital Universitario de Salamanca (Spain Salamanca)
🇪🇸Salamanca, Spain
Hospital Universitario Virgen del Rocio
🇪🇸Sevilla, Spain
Fundacion lnstituto Valenciano de Oncologia
🇪🇸Valencia, Spain
Hospital Clinico Universitario de Valencia
🇪🇸Valencia, Spain
Kantonsspital Winterthur
🇨🇭Winterthur, Zurich, Switzerland
Kantonsspital Baden.
🇨🇭Baden, Switzerland
Brust-Zentrum AG
🇨🇭Zürich, Switzerland
Changhua Christian Hospital
🇨🇳Changhua, Other, Taiwan
Changhua Christian Medical Foundation Changhua Christian Hospital
🇨🇳Changhua City, Taiwan
Kaohsiung Medical University Chung-Ho Memorial Hospital
🇨🇳Kaohsiung, Taiwan
Kaohsiung Medical University Hospital
🇨🇳Kaohsiung, Taiwan
Taipei Medical University-Shuang Ho Hospital, Ministry of Health and Welfare
🇨🇳New Taipei City, Taiwan
Taipei Medical University Hospital
🇨🇳New Taipei City, Taiwan
China Medical University Hospital
🇨🇳Taichung, Taiwan
Chi Mei Medical Center
🇨🇳Tainan City, Taiwan
National Cheng Kung University Hospital
🇨🇳Tainan, Taiwan
National Cheng-Kung University Hospital
🇨🇳Tainan, Taiwan
Chi Mei Hospital Liouying
🇨🇳Tainan, Taiwan
MacKay Medical Foundation The Presbyterian Church in Taiwan MacKay Memorial Hospital
🇨🇳Taipei City, Taiwan
Mackay Memorial Hospital
🇨🇳Taipei City, Taiwan
National Taiwan University Hospital
🇨🇳Taipei, Taiwan
Taipei Veterans General Hospital
🇨🇳Taipei, Taiwan
Koo Foundation Sun Yat-Sen Cancer Center
🇨🇳Taipei, Taiwan
Sun Yat-sen University Cancer Center
🇨🇳Taipei, Taiwan
Tri-Service General Hospital
🇨🇳Taipei, Taiwan
Central Hospital of the Ministry of National Defense
🇨🇳Taipei, Taiwan
Chang Gung Memorial Hospital LinKou
🇨🇳Taoyuan City, Taiwan
Chang Gung Memorial Hospital - Linkou
🇨🇳Taoyuan, Taiwan
Academic Oncology
🇬🇧London, England, United Kingdom
The Royal Marsden
🇬🇧London, United Kingdom
Finchley Memorial Hospital
🇬🇧London, United Kingdom
University College London Hospital (UCLH) NHS Foundation Trust
🇬🇧London, United Kingdom
University College London Hospitals NHS Foundation Trust
🇬🇧London, United Kingdom
The Royal Marsden NHS Foundation Trust (RM)
🇬🇧London, United Kingdom
Christie Hospital NHS Foundation Trust
🇬🇧Manchester, United Kingdom
The Christie NHS Foundation Trust
🇬🇧Manchester, United Kingdom