White Matter Plasticity in Schizophrenia
- Conditions
- Schizophrenia Disorders
- Registration Number
- NCT06641297
- Lead Sponsor
- University of Maryland, Baltimore
- Brief Summary
Schizophrenia spectrum disorders are associated with impairment in the microstructure of white matter, the key brain tissue responsible for fast communication between different brain regions necessary for any complex task. This white matter impairment is linked to problems with cognition in schizophrenia, especially slower processing speed. This project aims to study the potential for correcting white matter deficits in schizophrenia by examining mechanisms underlying white matter structure changes in response to training on playing a mock musical instrument.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 36
- Diagnosis of schizophrenia, schizoaffective disorder, schizophreniform disorder, or psychosis NOS
- age 15-45
- able to provide informed consent
- contraindications to MRI (metal implants, claustrophobia)
- medical condition that limits use of hands (ie, arthritis)
- Active or recent (within 6 months) substance use disorder other than nicotine
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method White matter microstructure 3 weeks fractional anisotropy of white matter tracts as assessed with diffusion tensor imaging
- Secondary Outcome Measures
Name Time Method Brain level of N-acetylaspartate 3 weeks NAA levels in motor cortex of brain as measured with magnetic resonance spectroscopy
Trial Locations
- Locations (2)
Maryland Psychiatric Research Center
🇺🇸Catonsville, Maryland, United States
University of Maryland Baltimore - Maryland Psychiatric Research Center
🇺🇸Catonsville, Maryland, United States