Validation of assessments for preclinical AD registratio
Not Applicable
Recruiting
- Conditions
- preclinical AD
- Registration Number
- JPRN-UMIN000030319
- Lead Sponsor
- ational Center for Geriatrics and Gerontology
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 180
Inclusion Criteria
Not provided
Exclusion Criteria
1) dementia, Parkinson's disease, multiple cerebral infarction, Huntington's disease, normal pressure hydrocephalus, brain tumor, progressive supranuclear palsy, epilepsia, subdural hematoma, multiple sclerosis, and head injury with after effect 2) detected infection or cerebral infarction by MRI 3) metallic substance in the body 4) major depression, bipolar disorder, alcohol or drug dependence, vitamin B12 deficiency, syphilis, and dysthyroidism 5) using psychoactive drug 6) having difficulty maintaining supine position 7) care-needs certification in the long-term care insurance system 8) HbA1c 6.5% or more
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Amyloid accumulation using Positron Emission Tomography (PET)
- Secondary Outcome Measures
Name Time Method Brain image: Magnetic Resonance Imaging (MRI) Cognitive function: Mini-Mental State Examination (MMSE), clinical dementia rating (CDR), National Center for Geriatrics and Gerontology-Functional Assessment Tool (NCGG-FAT): memory, attention, executive function, processing speed, working memory Blood sample: Single Nucleotide Polymorphism (SNP), DNA methylation, microRNA (miRNA), blood trace element Living situation: Medical condition, medication use, educational years, lifestyle, Activities of Daily Living (ADL), amount of conversation, quality of life (QOL), Geriatric Depression Scale (GDS)