Monitoring study of genomic mutations in patients with EGFR mutation or ALK translocation using plasma DNA - Monitoring of genomic mutations using plasma DNA

Plasma DNAs were collected from patietns with non-small cell lung cancer harboring EGFR mutations or ALK rearrangement. Paired samples such as at baseline and at progressive disease were collected. Next generation sequencing was performed to detect cancer-related somatic mutations using the plasma DNA including EGFR mutations and ALK rearrangement. We were able to track the changes in the variant allele frequency of those genes and identify the potential gene mutations responsible for drug resistance.