The influence of controlled dehydration and the antidiuretic hormone on blood coagulatio

Conditions: vochthuishouding
dehydration
fluid deficiency
10052547

Registration Number: NL-OMON35836

Lead Sponsor: Slotervaartziekenhuis

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: Not specified

Target Recruitment: 12

Inclusion Criteria

a. Adults >= 18 years old.
b. Able to provide informed consent.
c. Diagnosis of central diabetes insipidus (DI). (only for patients)

Exclusion Criteria

a. Strong suspection of an infection of any cause
b. Primary polydipsia and diabetes insipidus (for the healthy volunteers).
c. Untreated thyroid and adrenal hormone abnormalities.
d. Pregnancy or puerperium.
e. Common etiologies of the syndrome of inappropriate antidiuretic hormone (SIADH); Active malignancy, inflammatory diseases (multiple sclerosis, meningitis, systemic lupus erythematosus), acquired immuno- deficiency syndrome (AIDS), infections (tuberculosis, pneumonia, empyema) (only for those 6 patients without signs of infection), cystic fibrosis, drugs (Selective serotonine reuptake inhibitors, tricyclic antidepressants, carbamazepine, clofibrate, narcotics, antipsychotic drugs, cytotoxic drugs)
f. Potentiation of AVP antidiuretic effects: desmopressin, vasopressin, oxytocin, prostaglandin synthesis inhibitors

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Coagulation and fibrinolysis activation markers: F1+2 (fragment 1+2), ETP<br /><br>(endogenous thrombin potential), D-dimer, Plasminogen Activator Inhibitor-1<br /><br>(PAI-1) activity.<br /><br>Endothelial cell activation and platelet activation markers: von Willebrand<br /><br>factor activity (vWf:C), clotting factor VIII activity (fVIII:C).<br /><br>Blood coagulation time: PT. </p><br>

Secondary Outcome Measures