Comparative study of intrathecal dexmedetomidine &fentanyl as adjuvant to hyperbaric bupivacaine and hyperbaric bupivacaine alone in infraumbilical surgeries -prospective randomized controlled study.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- 1.Primary aim is to compare the duration of postoperative analgesia of dexmedetomidine and fentanyl given as adjuvants intrathecally to hyperbaric bupivacaine and hyperbaric bupivacaine alone
研究概览
简要总结
Various adjuvants have been used with local anaesthetics in spinal anaesthesia to avoid intraoperative visceral and somatic pain and to provide prolonged postoperative analgesia.
Aim: aim of this study is to compare postoperative analgesia duration,onset of sensory and motor block,hemodynamic changes (bradycardia,hypotension) of dexmedetomidine,fentanyl given intrathecally with bupivacaine and bupivacaine alone.
Materials and methods: 90 patients classified in American society of anesthesiologists classes 1 and 2 scheduled for infraumbilical surgeries will be studied.patients will be randomly allocated to receive 12.5mg hyperbaric bupivacine plus 10 microgram(group D,n=30) or hyperbaric bupivacine 12.5mg plus fentanyl 25micrograms (group F,n=30) or hyperbaric bupivacaine alone (group c,n=30)intrathecally.
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Not Applicable
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Age group 18 to 60 years
- •ASA 1 or 2
- •Presenting for infra umbilical surgeries.
排除标准
- •1.Patient allergic to drug
- •ASA 3 and 4( uncontrolled diabetes, uncontrolled hypertension, heart blocks, IHD patients) 3.Any contraindications to subarchnoid block.
结局指标
主要结局
1.Primary aim is to compare the duration of postoperative analgesia of dexmedetomidine and fentanyl given as adjuvants intrathecally to hyperbaric bupivacaine and hyperbaric bupivacaine alone
时间窗: 2nd hourly
次要结局
- Secondary aim will be to compare the onset of sensory and motor block, hemodynamic changes like bradycardia and hypotension of dexmedetomidine and fentanyl given intrathecally with hyperbaric bupivacaine and hyperbaric bupivacaine alone.(Every 2min)