Role of suctioning airway secretions in reducing lung infection in ICU patients requiring artificial breathing.

Phase 3

Suspended

Conditions: Ventilator associated pneumonia

Registration Number: CTRI/2011/06/001840

Lead Sponsor: Christian Medical College

Brief Summary: **This study is to assessthe role of subglottic suctioning in patients requiring mechanical ventilationin the Medical ICU. As a part ofstandard care in intubated patients, the secretions from the respiratory tract areperiodically suctioned through the endotracheal tube using sterile suctioncatheters. However it was shown in multiple observational studies that thesubglottic space between the vocal cords and the bulb of the ET tube harbors apool of secretions that are not accessible for routine suctioning. This pool ofsecretions forms a focus for colonization of various bacteria which are shownto be responsible for Ventilator Associated Pneumonia (VAP). VAP prolongs theduration of ICU stay as well the mortality of the patient. Also the financial burden due to a VAP is notonly the cost of additional ICU stay but also the second line antibiotics whichare often used in its treatment.**

**The central idea of thisstudy is an intervention enabling the clearance of the subglottic pool ofsecretions and its ability in prevention of VAP. Patients will be randomized toget either routine endotracheal suctioning alone or subglottic suctioning inaddition to the routine endotracheal suctioning. Subglottic suctioning is donethrough a port which opens into the subglottic region in specially designed ETtubes. Multiple randomized control trials world over have shown benefit withsubglottic suctioning in the prevention of VAP, however data from a developingcountries is lacking. We aim to show improved rates of VAP per ventilator days.**

Detailed Description: Not available

Recruitment & Eligibility

Status: Suspended

Sex: All

Target Recruitment: 320

Inclusion Criteria

All patients requiring Medical ICU admission for invasive mechanical ventilation will be recruited into the study.

Exclusion Criteria

Patients who are intubated elsewhere and are referred to CMC for admission are excluded from the trial.
Patients admitted to ICU for Non-invasive ventilation alone are excluded.
Tracheostomised patients are excluded.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Incidence of Ventilator associated pneumonia.	During the ICU stay.

Secondary Outcome Measures

Name	Time	Method
Time to VAP diagnosis	Mortality rate

Trial Locations

Locations (1): Christian Medical College
🇮🇳
Vellore, TAMIL NADU, India
Christian Medical College
🇮🇳Vellore, TAMIL NADU, India
DrVarsha Kiron
Principal investigator
09894365503
kironvarsha@gmail.com