Effectiveness of Neuromuscular Electrical Stimulation Versus Low-load Resistance Training With Blood Flow Restriction in Elderly Individuals With Sarcopenia
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 60
- 主要终点
- Change in Muscle Mass
研究概览
简要总结
To evaluate and compare the effectiveness of neuromuscular electrical stimulation (NMES) and low-load resistance training with blood flow restriction (BFR) in improving muscle mass, strength, functional performance, and quality of life in elderly individuals diagnosed with sarcopenia
详细描述
Sarcopenia, the age-related decline in muscle mass, strength, and function, significantly affects the health and independence of elderly individuals. It increases the risk of frailty, falls, and disability. Neuromuscular electrical stimulation (NMES) and low-load resistance training with blood flow restriction (BFR) are promising rehabilitation strategies for older adults with limited physical capacity. This study aims to compare the effectiveness of NMES and BFR in managing sarcopenia and improving physical and functional outcomes in the elderly
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Single (Participant)
盲法说明
This study uses single-blind masking. While participants are aware of their group assignment due to the nature of the interventions (especially NMES and resistance training), outcome assessors who perform the post-intervention evaluations (e.g., muscle strength, functional performance, and quality of life) will be blinded to group allocation. This is done to reduce assessment bias and ensure objective measurement of outcomes.
Additionally, the control group receives a placebo treatment (being connected to a non-active neuromusculoskeletal device), which helps reduce the psychological effects of knowing they are not receiving active intervention
入排标准
- 年龄范围
- 60 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Older age (≥ 60-75 years)
- •Low muscle strength (e.g., low handgrip strength)
- •Low muscle mass (e.g., ASM/height² below cutoff)
排除标准
- •heart disese
- •kidny disese
- •autoimune disese
- •cognetive disorder
- •sever form of sarcopenia
研究组 & 干预措施
Control Group
Participants receive placebo treatment by being connected to a neuromusculoskeletal device that is turned off (no actual stimulation), with no active intervention during the 8-week period
干预措施: Neuromuscular Electrical Stimulation (NMES) Group,Resistance + BFR Group (Device)
Neuromuscular Electrical Stimulation (NMES) Group
Participants receive neuromuscular electrical stimulation (NMES) targeting the quadriceps and hamstrings, 30 minutes per session, 3 times per week for 8 weeks
干预措施: Neuromuscular Electrical Stimulation (NMES) Group,Resistance + BFR Group (Device)
Resistance + BFR Group
Participants perform low-load resistance training (30% 1RM) combined with blood flow restriction using pneumatic cuffs, 30 minutes per session, 3 times per week for 8 weeks
干预措施: Neuromuscular Electrical Stimulation (NMES) Group,Resistance + BFR Group (Device)
结局指标
主要结局
Change in Muscle Mass
时间窗: 2 month
Assessed using Bioelectrical Impedance Analysis (BIA) to measure skeletal muscle mass. Evaluation is done pre- and post-intervention to detect changes in the Skeletal Muscle Index (SMI), based on EWGSOP2 criteria
次要结局
- Muscle Strength Handheld dynamometer (e.g., MicroFET)(2 month)
- Timed Up and Go (TUG) Test(2 month)
研究者
Ola Mohamed Elsayed Elgohary
ola mohamed elsayed elgohary
Pharos University in Alexandria