The efficacy of specific hepatitis B virus (HBV) vaccination, in Intradermal form, in healthy carriers of HBV to eliminate virus
Phase 3
- Conditions
- Hepatitis B.
- Registration Number
- IRCT138706131155N3
- Lead Sponsor
- guilan university of medical siences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 94
Inclusion Criteria
Including hepatitis B healthy carriers (positive HBsAg with normal alanine transaminase level).
Excluding D.M or other autoimmune diseases, chronic or serious medical diseases, malnutrition, positive for anti-HIV, anti-HCV and Anti-HDV, pregnancy, receiving any antiviral medication, alcohol intake daily, refusing to give informed consent and so increase in ALT or getting a serious disease during the project and volunteer refusing to continue.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method ndetectable HBV-DNA. Timepoint: 6th month and 12th month. Method of measurement: PCR.;Loss of HBsAg and appearance of anti-HBs. Timepoint: 6th month and 12th month. Method of measurement: ELIZA test.
- Secondary Outcome Measures
Name Time Method Clinical situation and possibly side effects. Timepoint: monthly. Method of measurement: clinically.