To Assess the Efficiency of local Application of Vancomycin powder, alongside standard intravenous antibiotics in patients undergoing Total Hip and Knee Replacement surgeries through a Randomized Controlled Trial.
Phase 3
- Conditions
- Health Condition 1: O- Medical and SurgicalHealth Condition 2: O- Medical and Surgical
- Registration Number
- CTRI/2024/04/065612
- Lead Sponsor
- JSS Academy of Higher Education and Research
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
All individuals aged 18 years or older who have been admitted in JSS Hospital, Mysuru and are undergoing elective THR, TKR will be used.
Exclusion Criteria
1) Patients with sepsis, hemodynamic instability or displayed signs of active infection(septic arthritis)
2)Patients with a known allergy to Vancomycin (itchiness, swelling, anaphylactic reaction).
3)Patients undergoing revision THR and Revision TKR.
4)Patients who are immunocompromised.
5)Patients who had previous surgery or history of radiation therapy at the surgical site.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To evaluate the efficacy of local application of Vancomycin powder in preventing Surgical Site Infections in patients undergoing Total Hip Replacement and Total Knee Replacement SurgeriesTimepoint: The time points during which the patients would be assessed are preoperatively, postoperative period (2nd, 5th and tenth day), 2nd week, 6th week, 3rd month, 6th month and 1 year after surgery.
- Secondary Outcome Measures
Name Time Method To assess the adverse effects of intrawound application of Vancomycin PowderTimepoint: Postopertive period, 2nd week, 6th week, 3rd month, 6th month and 1 year after surgery.