A study comparing cancer patients randomly assigned to be offered either genetic testing ‘at home’ or in hospital

Not Applicable

• Conditions: Patients diagnosed with colorectal, endometrial, or ovarian cancer eligible for genetic testing for cancer susceptibility gene variants; Cancer

• Registration Number: ISRCTN57402067
• Lead Sponsor: Queen Mary University of London

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2023-07-26
• Last Update Posted: 21 May 2024
• Study Completion: 2028-10-01

Recruitment & Eligibility

• Status: Ongoing
• Sex: All
• Target Recruitment: 832

Inclusion Criteria

1. Adults diagnosed with endometrial cancer or colorectal cancer fulfilling NHS clinical genetic testing criteria for mismatch repair genes based on clinical or histo-pathological molecular profile
or
2. Adults diagnosed with high-grade epithelial ovarian cancer fulfilling NHS clinical genetic testing criteria

Exclusion Criteria

Current exclusion criteria as of 09/05/2024:

1. Patients who have had previous genetic testing for Lynch Syndrome, OC, or CRC genes
2. Patients whose family has a known pathogenic variant in a cancer susceptibility gene, which is part of the panel the patient is eligible for undergoing testing.
3. Unable to provide informed consent

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Previous exclusion criteria:

1. Patients who have had previous genetic testing for Lynch Syndrome, or OC genes
2. Patients whose family has a known pathogenic variant in one of the following genes: BRCA1, BRCA2, RAD51C, RAD51D, BRIP1, PALB2, MLH1, MSH2, MSH6, PMS2
3. Unable to provide informed consent

Study & Design

• Study Type: Interventional
• Study Design: Not specified