Direct-to-patient testing at cancer diagnosis for precision prevention-2

Queen Mary University of London0 个研究点目标入组 832 人开始时间: 2023年7月26日最近更新: 2024年5月21日

适应症

试验速览

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•1. Adults diagnosed with endometrial cancer or colorectal cancer fulfilling NHS clinical genetic testing criteria for mismatch repair genes based on clinical or histo-pathological molecular profile
•2. Adults diagnosed with high-grade epithelial ovarian cancer fulfilling NHS clinical genetic testing criteria

•Current exclusion criteria as of 09/05/2024:
•1. Patients who have had previous genetic testing for Lynch Syndrome, OC, or CRC genes
•2. Patients whose family has a known pathogenic variant in a cancer susceptibility gene, which is part of the panel the patient is eligible for undergoing testing.
•3. Unable to provide informed consent
•Previous exclusion criteria:
•1. Patients who have had previous genetic testing for Lynch Syndrome, or OC genes
•2. Patients whose family has a known pathogenic variant in one of the following genes: BRCA1, BRCA2, RAD51C, RAD51D, BRIP1, PALB2, MLH1, MSH2, MSH6, PMS2
•3. Unable to provide informed consent

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