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Clinical Trials/ISRCTN57402067
ISRCTN57402067
Active, not recruiting
未知

Direct-to-patient testing at cancer diagnosis for precision prevention-2

Queen Mary University of London0 sites832 target enrollmentJuly 26, 2023
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Overview

Phase
未知
Intervention
Not specified
Conditions
Not specified
Sponsor
Queen Mary University of London
Enrollment
832
Status
Active, not recruiting
Last Updated
last year
OverviewInvestigatorsEligibility CriteriaOutcomesSimilar Trials

Overview

Brief Summary

No summary available.

Registry
who.int
Start Date
July 26, 2023
End Date
October 1, 2028
Last Updated
last year
Study Type
Interventional
Sex
All

Investigators

Eligibility Criteria

Inclusion Criteria

  • •1\. Adults diagnosed with endometrial cancer or colorectal cancer fulfilling NHS clinical genetic testing criteria for mismatch repair genes based on clinical or histo\-pathological molecular profile
  • •2\. Adults diagnosed with high\-grade epithelial ovarian cancer fulfilling NHS clinical genetic testing criteria

Exclusion Criteria

  • •Current exclusion criteria as of 09/05/2024:
  • •1\. Patients who have had previous genetic testing for Lynch Syndrome, OC, or CRC genes
  • •2\. Patients whose family has a known pathogenic variant in a cancer susceptibility gene, which is part of the panel the patient is eligible for undergoing testing.
  • •3\. Unable to provide informed consent
  • •Previous exclusion criteria:
  • •1\. Patients who have had previous genetic testing for Lynch Syndrome, or OC genes
  • •2\. Patients whose family has a known pathogenic variant in one of the following genes: BRCA1, BRCA2, RAD51C, RAD51D, BRIP1, PALB2, MLH1, MSH2, MSH6, PMS2
  • •3\. Unable to provide informed consent

Outcomes

Primary Outcomes

Not specified

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