Assessment of Drug Resistance Molecular Markers in Asymptomatic Malaria Among Migrant Workers in Myanmar
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 765
- 试验地点
- 1
- 主要终点
- Prevalence of the asymptomatic infection among the study population
研究概览
简要总结
A cross-sectional study will be conducted in selected 2 sentinel sites for assessment of drug resistance falciparum and vivax among asymptomatic infection in migrant workers in Myanmar.
详细描述
Although malaria prevalence is decreasing in Myanmar, drug resistance threatens the malaria elimination by 2030 especially high risk persons including migrant population. Previous study indicated that asymptomatic malaria parasite carried drug resistance gene such as K13 mutant that is genetically responsible for artemisinin resistant falciparum malaria. These asymptomatic carries may be a source to spread the disease and it is very important to conduct the surveillance on drug resistance status among high vulnerable persons. Unfortunately, there is no study to assess the drug resistance molecular markers in asymptomatic malaria among migrant workers in Myanmar. Therefore, this study fulfills the gaps of knowledge on important of asymptomatic hidden infection exploring to formulate the recommendation for elimination of malaria in Myanmar.
In this study, asymptomatic infections are screened by rapid diagnostic test, microscopy and molecular methods.
研究设计
- 研究类型
- Observational
- 观察模型
- Ecologic Or Community
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age above 6 year
- •Migrant population (moving from their normal residence place and working at a new place such as forest related activities, gold-mines or plantation sites for more than 3 months- 3 years)
- •Participant who give informed-consent to participate the study
排除标准
- •Known clinical malaria cases regardless of the species detected
- •Patients with clinical symptoms of malaria at the time of examination
- •Known history of malaria within 14 days
结局指标
主要结局
Prevalence of the asymptomatic infection among the study population
时间窗: 1 week
Number of the hidden malaria cases by RDT, microscopy or nested PCR (molecular method)
Proportion of the drug resistance molecular markers among asymptomatic infections
时间窗: 3 months
Among the asymptomatic cases, molecular markers will be analyzed (K13 and pfmdr1 copy number for falciparum and pvcrt-o, pvmdr1, pvdhps and pvdhfr gene analysis for vivax cases by Sanger Sequencing.
次要结局
未报告次要终点
研究者
Myat Htut Nyunt
Principal Investigator
Department of Medical Research, Lower Myanmar