Free circulating tumour DNA in patients with peritoneal metastases of colorectal origin and HIPEC therapy; LIBEC trial - a feasibility study
Completed
- Conditions
- Peritoneal metastases1001799010017991
- Registration Number
- NL-OMON43017
- Lead Sponsor
- Vrije Universiteit Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 44
Inclusion Criteria
- Orally and written informed consent
- Age 18 years and older
- Elective cytoreductive surgery followed by HIPEC
- Peritoneal metastases only
- Regular preoperative work-up
Exclusion Criteria
- Patients who are legally or mentally incapable or unable to give informed consent
- Patients younger than 18 years
- Presence of liver metastases on CT-scan
- Presence of pulmonary metastases on CT-scan
- Anxiety for vena puncture
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Plasma levels of ctDNA preoperatively and postoperatively<br /><br><br /><br>-qualitative: is mutated ctDNA detectable yes or no?<br /><br>-quantitative: the ratio between the number of mutated ctDNA reads to the total<br /><br>number of ctDNA reads </p><br>
- Secondary Outcome Measures
Name Time Method <p>Patient characteristics<br /><br>Tumour characteristics<br /><br><br /><br>Descriptives only.</p><br>