A Randomized comparative clinical study of Bhringarajaadi Taila and Gunjaadi Taila as external application in the management of Darunaka with special reference to dandruff.
Trial Snapshot
- Phase
- Phase 2/3
- Status
- Not yet recruiting
- Sponsor
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- relief in Darunaka(Dandruff)
Study Overview
Brief Summary
Thereis nothing like healthy hair to make an individual feel confident andbeautiful. Unhealthy hair is always a reason of concern not just for femalesbut also for males. Damaged hair and scalp are always frustrating factor foryouth. Hair is associated with youthfulness and beauty in women and muscularityin men; so, it is no surprise that hair loss can make any men and women feelself-conscious. Pollution. unhygienic conditions and many more factors cancause hair problem.
Darunaka is classified as one among kapalagataroga byAcharya Vagbhatta & Sharangdhara and one among kshudrarogaby Acharya Sushruta & others. Darunaka is characterized by kandu(itching),keshbhoomiprapatyate(scaling of the scalp), rukshata (dryness androughness of scalp) etc and all these symptoms are due to vitiation of Kaphaand Vata doshas[1].
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Darunaka can be correlated to dandruff in contemporaryscience. Dandruff is a common disorder affecting half of the population at thepre pubertal age and of any gender and ethnicity.[2] Dandruff isaffecting the scalp and can be an embarrassing condition. Dandruff isrestricted to the scalp and involves itchy flaking skin without visibleinflammation. Seborrheic dermatitis affects the scalp as well as face, retro-auricular area and the upper chest, causing flaking, scaling, inflammation andpruritis and can have marked erythema.[3]
Theword dandruff (dandruff, dandriffe) is of Anglo-Saxon origin, a combination of‘tan’ meaning ‘tetter’ and ‘drof’ meaning ‘dirty’. Dandruff affects aestheticvalue and often causes itching. It has been well established that keratinocytesplay a key role in the expression and generation of immunological reactionsduring dandruff formation.[4]
Thereare several microbial and nonmicrobial causes of dandruff like over shampooing,frequent combing, dust, dirt, dry skin, Seborrheic dermatitis sensitivity tohair care products or yeast. Among the several etiopathology pathway’s role oflipophilic yeast belongs to genus Malassezia was widely accepted. Seven speciesof Malassezia (i.e., M. globose, M. restricta, M. obtuse, M. sloofiae,M.sympodialis, M.furfur and M. pachydermatis) have been recognized in dandruffformation.(5) Among these, Malassezia globose and Malasseziarestricta are recognized as the most important pathogenic organisms in thedevelopment of dandruff.[6]
Inthe current scenario many chemical substances are in use for treating dandruffand these agents have certain limitation such as recurrence of dandruff andtheir harmful effects on skin after using it for long period are common. GunjaadiTaila and Bhringarajaadi Taila are medicinal preparations mentionedin Yogaratanakara which are small and simple preparations being used in *Darunaka.*All ingredients of both Taila are easily available and cheaper incost so every patient can afford easily. Comparison of Gunjaadi Taila,Kantkari Taila and Tila Taila has been done in our departmentpreviously in which GunjadiTaila found more effective in comparison to KantkariTaila and *Tila Taila.*So we are comparing here Bhringarajaadi Tailawith Gunjaadi Taila. Therefore, this study is planned to evaluate andcompare the efficacy of Bhringarajaadi Taila and Gunjaadi Tailain the patients of darunaka (dandruff).
Study Design
- Study Type
- Interventional
- Allocation
- Computer generated randomization
- Masking
- Open Label
Eligibility Criteria
- Ages
- 18.00 Year(s) to 60.00 Year(s) (—)
- Sex
- All
Inclusion Criteria
- •1 Patients of irrespective gender & socio-economic status.
- •2 Patients between age group of 18-60 years.
- •3 Patients with symptoms of Darunaka (Dandruff).
- •4 Known cases of Darunaka (Dandruff) who are willing to participate to study.
Exclusion Criteria
- •1 Patients with clinically significant systematic disease eg.
- •Immunological deficiency, AIDS, current malignancies, uncontrolled diabetes mellitus etc.
- •2 Other scalp disorders like Psoriasis, Tinea capitis etc.
- •3 Pregnant and lactating woman 4 Systemic treatment with corticosteroids, antibiotics, immune suppressants etc, or topical treatments applied to the scalp within 7 days before inclusion in the study and that could interfere with the results of the study like ketoconazole, antidandruff shampoo etc.
Outcomes
Primary Outcomes
relief in Darunaka(Dandruff)
Time Frame: 6 Weeks
Secondary Outcomes
- Relief in itching(Control in hair fall)