A clinical study comparing effectiveness of intranasal versus intravenous dexmedetomidine for attenuation of hemodynamic responses of laryngoscopy and endotracheal intubation n patients undergoing general anaesthesia.
Trial Snapshot
- Phase
- Phase 3 4
- Status
- Not yet recruiting
- Sponsor
- Enrollment
- 80
- Locations
- 1
- Primary Endpoint
- Heart Rate
Study Overview
Brief Summary
There are many literature regarding intravenous dexmedetomidine in attenuating the response to laryngoscopy and intubation but there is a lack of enough literature regarding intranasal use of dexmedetomidine for attenuation of response to laryngoscopy and intubation. Intranasal route is helpful preferred as it avoids needle anxiety and semi invasive.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Masking
- Participant and Investigator Blinded
Eligibility Criteria
- Ages
- 18.00 Year(s) to 60.00 Year(s) (—)
- Sex
- All
Inclusion Criteria
- •ASA (American Society of Anesthesiologists) grade 1 and 2.
Exclusion Criteria
- •Patient refused to participate Patient with known allergy and hypersensitivity to study drug.
Outcomes
Primary Outcomes
Heart Rate
Time Frame: Baseline,10 minute, 20 minute, 30 minute, 40 minute, At Induction, At laryngoscope and Intubation, 1minute, 2 minute, 3minute, 4 minute, 7 minute, 10 minute.
Systolic Blood Pressure
Time Frame: Baseline,10 minute, 20 minute, 30 minute, 40 minute, At Induction, At laryngoscope and Intubation, 1minute, 2 minute, 3minute, 4 minute, 7 minute, 10 minute.
Diastolic Blood Pressure
Time Frame: Baseline,10 minute, 20 minute, 30 minute, 40 minute, At Induction, At laryngoscope and Intubation, 1minute, 2 minute, 3minute, 4 minute, 7 minute, 10 minute.
MAP (Mean arterial pressure)
Time Frame: Baseline,10 minute, 20 minute, 30 minute, 40 minute, At Induction, At laryngoscope and Intubation, 1minute, 2 minute, 3minute, 4 minute, 7 minute, 10 minute.
Secondary Outcomes
- Post-operative sedation(Ramsay sedation score)(Baseline, At Intubation, 1 Hour, 2 Hour, 4 Hour, 6 Hour.)
Investigators
PAVANKUMAR S HANDRAL
Subharti Medical College