Objective Perimetry in Normal Subjects,Glaucoma Patients and Retinitis Pigmentosa Patients .
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- PLR response amplitude and latency
研究概览
简要总结
Objective perimetry can better monitor visual field defects in RP and Glaucoma patients than conventional subjective perimetry.The PLR ( Pupil Light Reflex ) of the short and long wave ratio should be significantly higher in areas of visual field defects in RP and Glaucoma patients.
详细描述
Pupil light reflex will be measured by a pupillometer in response to short and long wavelength light small spot stimulus in different area of the visual field. The PRL will be measured in four quadrant, central, 10, 20, and 30 degree from the visual axis.
Stimulus duration will be 1000 ms (1 sec), with intervals of 890 ms between stimuli. The stimuli size V with light intensity of 39.8 cd-s/m2 for both short wavelength stimuli (peak 485 nm) and long wavelength stimuli (peak 620nm).
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Sign on informed consent
- •Papillary response to light.
- •Groups of : Normal , Glaucoma patients with early glaucoma damage on HVF (nasal step ect. ), Glaucoma patients with advanced glaucoma damage on HVF (arcuate , tubular vision ) and RP patients (Early VF damage , ring scotoma ) .
- •Refractive correction up to -3.5 D.
排除标准
- •Cloudy corneas.
- •Surgical intraocular ophthalmic procedure within the past 30 days.
- •Nonreactive pupils.
- •Synechia of the iris to the lens after surgery or inflammation .
- •Neovascularization.
- •Iris coloboma.
- •Sphincter damage due to ischemia or trauma (tears of sphincter or diffuse damage to muscle).
- •Sphincter damage due to high intraocular pressure .
- •Iris tumor or cyst .
- •Ectropion uvea .
- •Adie's pupil .
- •Optic neuropathy with the potential for producing a positive RAPD (Relative Afferent Pupillary Defect ).
- •Chronic use of myotics or mydriatics.
- •Systemic Medication which affect on papillary response .
- •Any condition preventing accurate measurement or examination of the pupils.
结局指标
主要结局
PLR response amplitude and latency
时间窗: Not defined yet
次要结局
未报告次要终点
研究者
Dr. Ygal Rotenstreich
Director, Electrophysiology Clinic, Goldschleger Eye Institute
Sheba Medical Center