The Role of Prostaglandin and Anti-oxidant Availability on Recovery From Forearm Ischemia-reperfusion Injury in Humans
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 12
- 试验地点
- 1
- 主要终点
- Change in flow mediated dilation
研究概览
简要总结
The purposes of this study are two-fold. The first purpose is to determine the effect of taking vitamins on the recovery of an artery (blood vessel) following an induced temporary injury. The second purpose is to determine whether a specific vasodilator is less abundant after the injury and whether this contributes to increased constriction or after the injury. Finally, does vitamin consumption have an effect on the recovery from the injury if one of the substances in the blood that causes vessels to enlarge (dilate) is stopped?
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy males
- •Healthy females
排除标准
- •Cardiovascular disease
- •Peripheral vascular disease
- •Neurological deficits
- •Diabetes Type I or II
- •Pregnant women
- •Adverse reactions to Ibuprofen
研究组 & 干预措施
Antioxidant load
Trial to determine the impact of an antioxidant load before the ischemic injury on vascular function recovery
干预措施: Antioxidant (Dietary Supplement)
Prostaglandin inhibition
Trial to determine the impact of a non-selective prostaglandin inhibitor before the ischemic injury on vascular function recovery
干预措施: Prostaglandin inhibitor (Ibuprophen) (Drug)
Combined
Trial to determine the impact of an antioxidant load and prostaglandin inhibitor before the ischemic injury on vascular function recovery
干预措施: Antioxidant (Dietary Supplement)
Combined
Trial to determine the impact of an antioxidant load and prostaglandin inhibitor before the ischemic injury on vascular function recovery
干预措施: Prostaglandin inhibitor (Ibuprophen) (Drug)
结局指标
主要结局
Change in flow mediated dilation
时间窗: Change from baseline at 15 minutes after ischemia-reperfusion injury
Flow mediated dilation is a measure of vascular function and is measured as the outcome before and after an injury to the inner lining of the artery.
次要结局
- Change in low flow mediated constriction(Change from baseline at 15 minutes after ischemia-reperfusion injury)
研究者
Mark Rakobowchuk
Principle Investigator
University of Essex