Activity of Brown Adipose Tissue during hypoglycaEmia - ABATE

Academisch Medisch Centrum0 个研究点目标入组 16 人开始时间: 待定最近更新: 2024年5月6日

适应症

试验速览

暂无简介。

•Inclusion criteria for healthy volunteers
•* Caucasian race
•* 18-50 years old
•* BMI 20-28 kg/ m2
•* Subjects should be able and willing to give informed consent;Inclusion criteria for type 1 diabetes patients
•* Caucasian race
•* Age 18-50 years
•* BMI 20-28 kg/ m2
•* Type 1 Diabetes Mellitus
•* Subjects should be able and willing to give informed consent

•Exclusion criteria for healthy volunteers
•* Use of prescription medications (beta-adrenoreceptor blockers)
•* Cardiac history (previous arrhythmia)
•* History of epilepsy
•* Acute illness within 3 months before the study
•* Significant renal impairment (creatinine clearance <50ml/min)
•* Family history of diabetes;Exclusion criteria for type 1 diabetes patients
•* Impaired awareness of hypoglycaemia
•* Evidence of severe diabetes complications (autonomic neuropathy, macroalbuminuria, proliferative retinopathy)
•* Use of beta-adrenoreceptor blockers
•* Cardiac history (previous arrhythmia)
•* History of epilepsy
•* Acute illness within 3 months before the study
•* Significant renal impairment (creatinine clearance <50ml/min)

发起方