To Investigate the Immediate Effect of Birth on Immunological Parameters in Cord Blood, and Compare With Data of CS Born Infants Collected in the JULIUS SN Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 主要终点
- Allergen Stimulated Cytokine Expression in the Supernatants of Cord Blood Mononuclear Cells (CBMC)
研究概览
简要总结
The purpose of the study is to understand the immediate effect of birth on immunological parameters in vaginally born cord blood.
详细描述
The main purpose of the study is to understand the immediate effect of birth on immunological parameters in vaginally born cord blood and also whether mode and duration of delivery has an influence on immune parameters in cord blood.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Pregnant mothers undergoing normal vaginal delivery
排除标准
- •Use of non-steroidal anti-inflammatory drugs (NSAIDs) 2 weeks prior to birth
- •Antenatal antibiotics treatment (2 weeks prior to birth)
- •Diabetes mellitus requiring insulin treatment during pregnancy
- •Uncontrollable Hyperthyroidism during pregnancy
结局指标
主要结局
Allergen Stimulated Cytokine Expression in the Supernatants of Cord Blood Mononuclear Cells (CBMC)
时间窗: 1 year
Cellular response to allergen stimulation will be measured in supernatants of cultured cord blood mononuclear cells.
Cytokines Profile in Cord Blood Plasma
时间窗: 1 year
Following cytokines will be part of the profile: IL-6, IL-1, IL-2, IL-4, IL-5, IL-7, IL-8, IL-10, IL12p70, IL-13, IL-17, G-CSF, GM-CSF, IFNg, MCP-1(MCAF), MIP-1b, TNFa
Cord Blood Immunoglobulin Levels
时间窗: 1 year
Immunoglobulin levels will be measured in cord blood plasma
次要结局
未报告次要终点