The Relationship Between the Change of Resting Energy Expenditure(REE) and Nutritional Status in Peritoneal Dialysis(PD) Patients With Peritonitis.
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- The relationship between the change of REE and the change of albumin
研究概览
简要总结
Peritonitis is a common and devastating complication in patients on peritoneal dialysis (PD). It is a known fact that persistent inflammatory state and nutritional deterioration are closely associated with increased mortality in PD patients.And resting energy expenditure(REE) is significantly increased in acute and chronic inflammation in patients with chronic kidney disease (including dialysis patients).However,it is limited to the changing trend and duration of REE in peritonitis.Investigators hypothesize that the increase in total energy consumption resulting from the increase of REE which may accompany with decreased energy intake will lead to negative energy balance and nutritional deterioration, which may affect the prognosis of patients.Therefore,a prospective cohort study will be designed to dynamically research the change of REE accompanied with the nutrition status in peritonitis and provide the basis for peritonitis management in the future.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Receiving PD for>3 months
- •Age between 18 and 80 years
- •Confirm diagnosis of peritonitis
排除标准
- •Disability
- •Other acute complications: including systemic infections except for peritonitis, acute cardia-cerebrovascular disease in one month
- •Active hepatitis and musculoskeletal diseases in the past
- •Cancer and is treated with chemoradiotherapy within 1 year
- •Severe edema of the whole body or a large amount of body cavity effusion
- •Thyroid dysfunction
- •History of hormonal drugs use
- •During pregnancy or lactation
- •Mental disorder
结局指标
主要结局
The relationship between the change of REE and the change of albumin
时间窗: 90 days
Method: REE, indirect calorimetry
次要结局
- The relationship between the change of REE and the change of BMI(90 days)
- The relationship between the change of REE and the change of Fat mass(90 days)
- The relationship between the change of REE and the change of handgrip strength(90 days)
- The relationship between the change of REE and the change of lean body mass(90 days)
研究者
Dong Jie
Clinical Professor in Renal Division, Department of Medicine
Peking University First Hospital