The Relationship Between the Change of Resting Energy Expenditure and Nutritional Status .

Recruiting

• Conditions: Resting Energy Expenditure; Nutrition; Peritonitis

• Registration Number: NCT03511950
• Lead Sponsor: Peking University First Hospital

Brief Summary

Peritonitis is a common and devastating complication in patients on peritoneal dialysis (PD). It is a known fact that persistent inflammatory state and nutritional deterioration are closely associated with increased mortality in PD patients.And resting energy expenditure(REE) is significantly increased in acute and chronic inflammation in patients with chronic kidney disease (including dialysis patients).However,it is limited to the changing trend and duration of REE in peritonitis.Investigators hypothesize that the increase in total energy consumption resulting from the increase of REE which may accompany with decreased energy intake will lead to negative energy balance and nutritional deterioration, which may affect the prognosis of patients.Therefore,a prospective cohort study will be designed to dynamically research the change of REE accompanied with the nutrition status in peritonitis and provide the basis for peritonitis management in the future.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2018-04-01
• Study First Submitted QC: 2018-04-27
• Study First Posted: 2018-04-30
• Study Start: 2021-04-01
• Status Verified: 2022-09
• Last Update Submitted: 2022-09-27
• Last Update Posted: 2022-09-29
• Primary Completion: 2023-08-30
• Study Completion: 2023-10-30

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Receiving PD for>3 months
• Age between 18 and 80 years
• Confirm diagnosis of peritonitis

Exclusion Criteria

• Disability
• Other acute complications: including systemic infections except for peritonitis, acute cardia-cerebrovascular disease in one month
• Active hepatitis and musculoskeletal diseases in the past
• Cancer and is treated with chemoradiotherapy within 1 year
• Severe edema of the whole body or a large amount of body cavity effusion
• Thyroid dysfunction
• History of hormonal drugs use
• During pregnancy or lactation
• Mental disorder

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The relationship between the change of REE and the change of albumin	90 days	Method: REE, indirect calorimetry

Secondary Outcome Measures

Name	Time	Method
The relationship between the change of REE and the change of BMI	90 days	The relationship between the change of REE and the change of BMI during 90 days after peritonitis
The relationship between the change of REE and the change of Fat mass	90 days	Method: REE, indirect calorimetry; Fat mass, Bioelectrical impedance
The relationship between the change of REE and the change of handgrip strength	90 days	The relationship between the change of REE and the change of handgrip strength during 90 days after peritonitis
The relationship between the change of REE and the change of lean body mass	90 days	Method: REE, indirect calorimetry; lean body mass, Bioelectrical impedance

Trial Locations

Locations (1)

Peking University First Hospital; 🇨🇳 Beijing, China