Effect of different antipsychotic medication on craving related brain activity in patients with schizophrenia and cannabis abuse or dependence:a randomized controlled study comparing clozapine and risperidone. - fMRI.Clozapine.Risperidon.Cannabis

Academisch medisch centrum, department of psychiatry0 个研究点开始时间: 2008年8月29日最近更新: 2012年3月19日

研究概览

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•Eligible for the study are male in- and outpatients age 18 to 30 (extremes included), of diverse ethnicity, meeting DSM-IV criteria for schizophrenia, schizoaffective - or schizophreniform disorder and cannabis abuse or dependence based on the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders (SCID-P). Women will not be included because co-morbid cannabis abuse or dependence occurs more frequent in men and the expected number of included subjects, therefore, would not allow separate analysis.
•We will also include schizophrenia patients without cannabis abuse or dependence and compare their outcomes with those of patients with co-occurring cannabis abuse or dependence.
•We will also include healthy controls for 1 fMRI scan only.
•All patients need to be abstinent for cannabis use minimally three days before assessment of functional craving pathways.
•Each patient must understand the nature of the study and must sign an informed consent document.
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range
•F.1.3 Elderly (>=65 years) no
•F.1.3.1 Number of subjects for this age range

•Exclusion criteria are (1) known hypersensitivity to any ingredient of clozapine or risperidone, (2)
•concomitant use of any antipsychotic drug other than clozapine or risperidone, (3) use of depot
•antipsychotics in the three months prior to inclusion, (4) use of psychotropic medications other than
•oxazepam or biperiden, (5) narrow angle glaucoma, (6) known neurological or endocrine disease, (7)
•presence of non-removable metal objects (8) myeloproliferative disorders, (9) unstable epilepsy, (10)
•agranulocytosis or leucopenia in the past (11) Current leukocyte level lower than 3.5 x 109/l, current
•neutrophilic granulocyte level lower than 2.0x 109/l .

发起方

Academisch medisch centrum, department of psychiatry