A Randomized Controlled Trial To Evaluate The Efficacy Of Panchtikta Ksheer Basti And Bisphosphonates On Bone Resorption Marker CTX-1 In The Management Of Osteoporosis

Osteoporosis is a chronic skeletal disorder characterized by low bone mass, deterioration of bone microarchitecture, and increased risk of fragility fractures. It is often referred to as a silent disease because bone loss occurs gradually without obvious symptoms until fractures occur. In Ayurveda Asthi- majja kshaya presents sign and symptoms that closely parallel to osteoporosis are asthishula, toda, sandhi shaithilya, kesha, loma, nakha, danta vikara, daurbalya, rukshata sparshashyatava.

Drug- 1. Bisphosphonates- 70mg weekly once through oral route purchased from Litnow Lifescience near pull bazar Narnaul.

2. Tikta ksheer Basti- 480 ml should be administered through rectal route for 15 days in 1st cycle and next 15 days in 2nd cycle prepared in BKNGAC & H.

Research Question: Does Tikta Ksheer Basti produce greater reduction in bone resorption marker serum CTX-I in osteoporosis.

Null Hypothesis: There is no significant difference between Tikta Ksheer Basti and Bisphosphonate on bone resorption marker serum CTX-I in osteoporosis.

Alternate Hypothesis: There is significant difference between Tikta Ksheer Basti and Bisphophonate on bone resorption marker serum CTX-I in osteoporosis.

Subjective Criteria- Detailed performa of Lakshans of Asthi Kshaya

Detailed performa of Lakshans of Vata Vriddhi.

Objective Criteria- i) BMI (ii) CTX-I  (iii) VAS Scale (iv) KNOOS Score (v) MRI If required (vi) Waist hip circumference

Expected Outcome -Anyone among Null and Alternate hypothesis will be outcome