Autonomic Nervous System and Nitric Oxide Interactions

Phase 1

Completed

• Conditions: Endothelial Dysfunction
• Interventions: Drug: Placebo; Drug: Trimethaphan

• Registration Number: NCT01137253
• Lead Sponsor: Vanderbilt University

Brief Summary

The investigators are interested in the role of the autonomic nervous system in the regulation of endothelial function among obese hypertensive subjects. In particular, the investigators will study how endothelial function (response to intra-arterial acetylcholine) changes during autonomic withdrawal.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-06
• Study First Submitted: 2010-06-01
• Study First Submitted QC: 2010-06-03
• Study First Posted: 2010-06-04
• Primary Completion: 2017-01
• Study Completion: 2017-01
• Status Verified: 2018-02
• Last Update Submitted: 2018-02-27
• Last Update Posted: 2018-02-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 21

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Placebo	Placebo	Response to intrabrachial vasodilators during saline intravenous (IV) infusion
Trimethaphan	Trimethaphan	Response to intrabrachial vasodilators during autonomic withdrawal

Primary Outcome Measures

Name	Time	Method
Endothelial Function	2 hours	The dose response curve to intrabrachial vasodilators will be determined using the peak forearm blood flow during the last 5 minutes of each drug infusion

Trial Locations

Locations (1)

Vanderbilt University Medical Center; 🇺🇸 Nashville, Tennessee, United States