The Autonomic Nervous System, Nitric Oxide and TPA Interactions

Vanderbilt University1 site in 1 country21 target enrollmentJune 2010

ConditionsEndothelial Dysfunction

InterventionsTrimethaphan Placebo

DrugsPlacebo Trimethaphan

Overview

Phase: Phase 1
Intervention: Trimethaphan
Conditions: Endothelial Dysfunction
Sponsor: Vanderbilt University
Enrollment: 21
Locations: 1
Primary Endpoint: Endothelial Function
Status: Completed
Last Updated: 8 years ago

Overview Investigators Eligibility Criteria Arms & Interventions Outcomes Sites Similar Trials

Overview

Brief Summary

The investigators are interested in the role of the autonomic nervous system in the regulation of endothelial function among obese hypertensive subjects. In particular, the investigators will study how endothelial function (response to intra-arterial acetylcholine) changes during autonomic withdrawal.

Registry

clinicaltrials.gov

Start Date

June 2010

End Date

January 2017

Last Updated

8 years ago

Study Type

Interventional

Study Design

Crossover

Sex

All

Investigators

Sponsor

Vanderbilt University

Responsible Party

Principal Investigator

Alfredo Gamboa

Research Assistant Professor

Vanderbilt University

Eligibility Criteria

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Arms & Interventions

Trimethaphan

Response to intrabrachial vasodilators during autonomic withdrawal

Intervention: Trimethaphan

Placebo

Response to intrabrachial vasodilators during saline intravenous (IV) infusion

Intervention: Placebo

Outcomes

Primary Outcomes

Endothelial Function

Time Frame: 2 hours

The dose response curve to intrabrachial vasodilators will be determined using the peak forearm blood flow during the last 5 minutes of each drug infusion