临床试验/NCT03951818

NCT03951818Unknown不适用

Observing the Changes of Endocrine and Metabolism in Patients With Thalassemia Major

National Taiwan University Hospital1 个研究点分布在 1 个国家目标入组 100 人开始时间: 2019年4月1日最近更新: 2021年2月18日

适应症

试验速览

阶段: 不适用
发起方: National Taiwan University Hospital
入组人数: 100
试验地点: 1
主要终点: Abnormal bone mineral density rate

研究概览研究设计入排标准结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

Patient with thalassemia major have many endocrine diseases, such as hypopituitarism, hypothyroidism, hypoparathyroidis, osteoporosis, and etc.. These problems may be due to anemia itself or related to iron deposition. This study aimed to investigate the endocrine aspect of thalassemia major patients in Taiwan in order to introduce early intervention or treatment in the future.

研究设计

研究类型: Observational
观察模型: Case Only
时间视角: Retrospective

入排标准

年龄范围: 20 Years 至 85 Years（Adult, Older Adult）
性别: All
接受健康志愿者: 否

入选标准

•Clinical diagnosis of Thalassemia major
•Patients of 20-85 years old

排除标准

•Patients younger than 20 years old.
•Patients older than 85 years old.
•Patients who are pregnant

结局指标

主要结局

Abnormal bone mineral density rate

时间窗: 10 years

abnormal bone mineral density is defined as T-score \< -1 SD in menopause women or men older than 50 years old, or Z score \< -2 SD in premenopausal women or men not older than 50 year old.

次要结局

abnormal thyroid function rate(10 years)
abnormal pituitary function rate(10 years)

研究者

发起方

National Taiwan University Hospital

申办方类型

Other

责任方

Sponsor

研究点 (1)

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