MusiCare: Protecting Cognitive Functions and Wellbeing Using Music Therapy & Innovative Technology With an Aging Population
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 210
- 试验地点
- 2
- 主要终点
- Executive and spatial-cognitive abilities change from baseline/post (i.e., time 0/+5 months)
研究概览
简要总结
The number of older people living with cognitive impairment or dementia has increased the need for simple, inexpensive interventions to improve the quality of life for such individuals and their families. Policy-makers sensitive to issues associated with mental health challenges in aging have embraced social prescribing, and a wealth of research has flourished to study non-pharmacological forms of preventative intervention. Can music-therapy(MT) be one of them? Different studies demonstrated that music stimulates a range of cognitive and social functions. However, scientific studies assessing the value of MT for those who need support in later life are limited, and rigorous research is required to generate robust scientific evidence. The focus of this study is on developing novel forms of intervention for older adults who are healthy or experiencing mild-to-moderate cognitive decline, aiming at [i]understanding whether MT could be used in preventive programs to support cognitive functions, [ii]identifying the best match between types of MT and levels of cognitive decline. Moreover, recent developments of Robotic-Assistance-Technologies offer opportunities to explore how such technologies may be used to contribute to older adults wellbeing when integrated within care routines to facilitate MT delivery.
Spanning across three-studies, the investigators will examine psychosocial benefits of 5-month MT interventions (one2one, small-group MT, large-group MT) in healthy older adults and impaired older adults in care homes, compared to standard care. This latter group will receive MT afterwards. Further, researchers will investigate whether Robotic-Assistance-Technologies may enrich MT interventions and have additional benefits for the participants and translatability for community-based services.
In order to measure these effects, psychological (cognitive functions, wellbeing, quality of life) and physiological (hormonal, cardiovascular & brain activity) measures will be compared before/after the intervention.
The study will elucidate relationships between different types of MT and benefits to participants wellbeing, cognitive functions & social engagement, as well as the impact of robotic assistive technologies in public health services and social care.
详细描述
The following objectives are addressed:
[Oi] Identifying a consistent set of convergent measures for the reliable assessment of cognition/well-being in MT studies integrating psychological measures with biomarkers; [Oii] Implementing robust MT protocols benefitting cognitive functions/well-being in ageing individuals with varying cognitive ability; [Oiii] Comparing the outcomes of one2one/small-group/large-group MT intervention in function of participants' cognitive abilities (ranging from healthy ageing to moderate impairment); [Oiv] Devising, implementing and testing a robotic platform associated with MT to facilitate therapists/caregivers' work through novel forms of interaction with ageing individuals, and potential translatability to communities.
Our research questions/hypotheses are:
[H1] Will MT benefits healthy, mildly and moderately impaired 65+ in outcome measures? MT > standard care.
[H2] Which MT treatment (one2one/small group/large group) is more effective in function of older adults' cognitive level? Best outcomes predicted as follows: healthy 65+ with small-group MT; for mildly impaired 65+, one2one = small-group MT<large group; moderately impaired 65+ with one2one MT.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 65 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Aged ≥65yrs
- •No significant hearing impairment that would negatively interfere with the music-based interventions
- •Fluent in English
- •Healthy group - MMSE ≥ 24
- •Cognitive impairment: mild MMSE= 18-23, moderate MMSE= 10-17
排除标准
- •Presence of severe motor deficits that would not allow individuals to participate in the intervention
- •Having taken part in a cognitive training programme or Music Therapy programme within the last 6 months.
结局指标
主要结局
Executive and spatial-cognitive abilities change from baseline/post (i.e., time 0/+5 months)
时间窗: Baseline vs. post- intervention period (time 0/+5-months)
Tangled Figure Test (Arcara et al., 2011) The test wants to evaluate participant's ability to perform figure-background discrimination and inhibition on the answers already provided as well as to recognize the contours of the figures. Mainly it is a test of visual recognition, but it requires the ability to reorganize a complex visual pattern in order to identify an increasing number of figures. Provides information on spatial-cognitive abilities, and executive and naming difficulties.
General cognitive functions change from baseline/post (i.e., time 0/+5 months)
时间窗: Baseline vs. post- intervention period (time 0/+5-months)
Mini-Mental State Examination (MMSE, Folstein et al., 1975): A world standardized tool for screening general cognitive function which allows the client to be placed on a cognitive functioning scale. This test is usually used to follow the course of a disease or for monitoring the response to a specific treatment, as in this case.
Attentional functions change from baseline/post (i.e., time 0/+5 months)
时间窗: Baseline vs. post- intervention period (time 0/+5-months)
TMT-A (Reitan \& Wolfoson, 1985) The test assesses selective attention and psychomotor speed.
Music related cognitive function change from baseline/post (i.e., time 0/+5 months)
时间窗: Baseline vs. post- intervention period (time 0/+5-months)
Music Cognitive Test (MCT, Mangiacotti, 2019; - et al., 2019b) A music-based cognitive test to measure cognitive functions typically stimulated by rehabilitative music interventions.
次要结局
- Quality of Life change from baseline/post (i.e., time 0/+5 months)(Baseline vs. post- intervention period (time 0/+5-months))
- Mood Index change from baseline/post (i.e., time 0/+5 months)(Baseline vs. post- intervention period (time 0/+5-months))
- Neuro-psychiatric symptoms change from baseline/post (i.e., time 0/+5 months)(Baseline vs. post- intervention period (time 0/+5-months))
- Cognitive reserve(Baseline (i.e., time 0))
- Quality of Life change from baseline/post (i.e., time 0/+5 months)(Baseline vs. post- intervention period (time 0/+5-months))
- Mood Index change from baseline/post (i.e., time 0/+5 months)(Baseline vs. post- intervention period (time 0/+5-months))
- Neuro-psychiatric symptoms change from baseline/post (i.e., time 0/+5 months)(Baseline vs. post- intervention period (time 0/+5-months))
- Cognitive reserve(Baseline (i.e., time 0))
- Wellbeing of Older People scale(Baseline vs. post- intervention period (time 0/+5-months))
- Sleep Quality Index(Baseline vs. post- intervention period (time 0/+5-months))
研究者
Anthony Mangiacotti
Lecturer in Psychology; Co-PI MusiCare Project
University of West London