Evaluation of the Efficacy of Intralesional Injection of Combined Digoxin and Furosemide Versus 5 - Fluorouracil in Treatment of Plantar Warts
试验速览
- 阶段
- 不适用
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- the change in number of plantar warts
研究概览
简要总结
Warts are common skin infections caused by human papillomavirus (HPV), which can cause a variety of skin presentations according to its type, site and the immune status .Nongenital warts may be presented as common, plane, plantar, filiform, or mucosal warts .Most people are affected by cutaneous warts, either plantar warts or common warts .prevalence of skin warts is between 3% and 13% and plantar warts are about 30% of skin warts in western world .Majority of cases occur in adolescent and young adults
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age:>18 years .
- •Sex: both males and females will be included.
- •Confirmed diagnosis by clinical and dermoscopic examination of plantar warts will be made
排除标准
- •Patients with history or evidenced hypersensitivity to any component used in this study.
- •Pregnancy & lactating.
- •Patients who receive immune suppressive therapy.
- •Patients who receive any wart treatment during the last 2 months before enrollment in the study.
- •Patients with systemic illness especially cardiac patients.
- •Patients who refused participation in the study
研究组 & 干预措施
group A
patients will receive intralesional combined digoxin and furosemide , one session every 2 weeks for maximum 6 sessions
干预措施: combined digoxin and furosemide (Drug)
group B
patients will receive intralesional 5 fluorouracil mixed with 1ml of 2% lignocaine and epinephrine one session every 2 weeks for maximum 6 sessions .
干预措施: 5 fluorouracil (Drug)
结局指标
主要结局
the change in number of plantar warts
时间窗: 3 month
measurement the change in number of plantar warts
the change in size of plantar wart
时间窗: 3 month
measurement the change in size of plantar wart
次要结局
未报告次要终点
研究者
Samah Ragab Ahmed
resident doctor at dermatology department at sohag teaching hospital
Sohag University