Evaluation of the Efficacy of Intralesional Injection of Combined Digoxin and Furosemide Versus 5 - Fluorouracil in Treatment of Plantar Warts

Not Applicable

• Conditions: Plantar Wart
• Interventions: Drug: 5 fluorouracil; Drug: combined digoxin and furosemide

• Registration Number: NCT05520658
• Lead Sponsor: Sohag University

Brief Summary

Warts are common skin infections caused by human papillomavirus (HPV), which can cause a variety of skin presentations according to its type, site and the immune status .Nongenital warts may be presented as common, plane, plantar, filiform, or mucosal warts .Most people are affected by cutaneous warts, either plantar warts or common warts .prevalence of skin warts is between 3% and 13% and plantar warts are about 30% of skin warts in western world .Majority of cases occur in adolescent and young adults

Detailed Description

Not available

Basic Information
|
Recruitment & Eligibility
|
Study & Design
|
Trial Locations

Study Timeline

• Study Start: 2022-07-01
• Status Verified: 2022-08
• Study First Submitted: 2022-08-15
• Study First Submitted QC: 2022-08-29
• Last Update Submitted: 2022-08-29
• Study First Posted: 2022-08-30
• Last Update Posted: 2022-08-30
• Primary Completion: 2022-09
• Study Completion: 2022-09

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Age:>18 years .
• Sex: both males and females will be included.
• Confirmed diagnosis by clinical and dermoscopic examination of plantar warts will be made

Read More

Exclusion Criteria

• Patients with history or evidenced hypersensitivity to any component used in this study.
• Pregnancy & lactating.
• Patients who receive immune suppressive therapy.
• Patients who receive any wart treatment during the last 2 months before enrollment in the study.
• Patients with systemic illness especially cardiac patients.
• Patients who refused participation in the study

Read More

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
group B	5 fluorouracil	patients will receive intralesional 5 fluorouracil mixed with 1ml of 2% lignocaine and epinephrine one session every 2 weeks for maximum 6 sessions .
group A	combined digoxin and furosemide	patients will receive intralesional combined digoxin and furosemide , one session every 2 weeks for maximum 6 sessions

Primary Outcome Measures

Name	Time	Method
the change in number of plantar warts	3 month	measurement the change in number of plantar warts
the change in size of plantar wart	3 month	measurement the change in size of plantar wart

Trial Locations

Locations (1)

Sohag University Hospital; 🇪🇬 Sohag, Egypt