The Neural Correlates of Cannabis Use
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 162
- 试验地点
- 1
- 主要终点
- CB1R availability using [11-C]OMAR PET imaging
研究概览
简要总结
The purpose of this research study is to determine the temporal course of recovery of CB1R availability and neural oscillations, in cannabis-dependent individuals at baseline, following 48 hour confirmed inpatient abstinence and after four weeks confirmed abstinence. This research will also examine associations between CB1R availability, neural oscillations and cognitive function.
详细描述
The purpose of this research study is to determine the temporal course of recovery of CB1R availability and neural oscillations, in cannabis-dependent individuals at baseline, following 48 hour confirmed inpatient abstinence and after four weeks confirmed outpatient abstinence (confirmed by tracking creatinine adjusted urine THC-COOH levels). This research will also examine associations between CB1R availability, neural oscillations and cognitive function using [11-C]OMAR PET imaging and electroencephalography.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Other
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Cannabis Dependent Subjects
- •Current cannabis consumption
- •Willing to abstain from cannabis use for four weeks
- •Inclusion Criteria for Healthy Controls
- •No current cannabis consumption
排除标准
- •MRI metal exclusions and claustrophobia
- •Education completed is less than 12 years
研究组 & 干预措施
Cannabis Dependent Subjects
Subjects who are frequent cannabis users
干预措施: [11-C]OMAR (Drug)
Healthy Controls
Subjects with no current cannabis use
干预措施: [11-C]OMAR (Drug)
结局指标
主要结局
CB1R availability using [11-C]OMAR PET imaging
时间窗: Change in CB1R availability from baseline to 48 hours and 28 days
Change in CB1R availability (e.g. volume distribution).
次要结局
- Changes in Cognition during withdrawal using a computerized battery(Change in CB1R availability from baseline to 48 hours and 28 days)
- Changes in brain rhythms measured by Electroencephalography(Change in CB1R availability from baseline to 48 hours and 28 days)
研究者
Mohini Ranganathan
Associate Professor
Yale University