Comparative study of the duration of post operative analgesia with different doses of intrathecal Dexmedetomidine as adjuvant to 0.5% Hyperbaric Bupivacaine & with Bupivacaine alone in Total Abdominal Hysterectomy surgeries. - randomized double blind study.
试验速览
- 阶段
- 1/2 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- Dexmedetomidine 10 mcg was a better adjuvant compared to 5 mcg in terms of better post operative analgesia when used as intrathecal adjuvant to Bupivacaine in subarachnoid block
研究概览
简要总结
This study is being undertaken to evaluate and compare the duration of postoperative analgesia with different doses of intrathecal Dexmedetomidine , as adjuvant to Bupivacaine in Total Abdominal Hysterectomy surgeries , and their side effect profile ( As evidenced by Hypotension and Bradycardia ).Dexmedetomidine 10 mcg was a better adjuvant compared to 5 mcg in terms of better post operative analgesia without increased incidence of side effects when used as intrathecal adjuvant to Bupivacaine in subarachnoid block
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Double Blind Double Dummy
入排标准
- 年龄范围
- 35.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- Female
入选标准
- •ASA I & ASA II PATIENTS SCHEDULED TOTAL ABDOMINAL HYSTERECTOMY.
排除标准
- •Patients with baseline Heart rate < 60 or on Beta blockers / Alpha agonist.
- •Patient refusal for study participation .
- •Local infection at injection site.
- •Presence of any coagulopathies or bleeding disorders or patients on anticoagulation.
- •PRESENCE OF NEUROLOGICAL DEFICITS, PERIPHERAL NEUROPATHIES, MYOPATHIES, OR CHRONIC PAIN IN THE OPERATING LIMB.
- •PATIENTS WITH KNOWN ALLERGY TO LOCAL ANAESTHETICS OR TO ANY STUDY DRUGS TO BE USED.
- •HEMODYNAMICALLY COMPROMISED PATIENTS ALCOHOLIC/ PSYCHIATRIC/UNCOOPERATIVE PATIENTS PATIENTS WITH HEPATIC / RENAL OR CARDIOPULMONARY DISORDERS.
- •PATIENTS LESS THAN 5 FEET HEIGHT.
- •TOTAL ABDOMINAL HYSTERECTOMY TAKING > 3 HRS.
结局指标
主要结局
Dexmedetomidine 10 mcg was a better adjuvant compared to 5 mcg in terms of better post operative analgesia when used as intrathecal adjuvant to Bupivacaine in subarachnoid block
时间窗: Post operative analgesia assessed every 6 hours after the requirement of first dose of analgesic
次要结局
- Onset of sensory block(Onset of motor block)