Effects of a Strength Physical Exercise Program in Colorectal Cancer Patients Undergoing Chemotherapy Treatment
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 40
- 主要终点
- Chemotherapy-induced neuropathy
研究概览
简要总结
Chemotherapy is a crucial treatment in the fight against colon cancer, but unfortunately, its impact is not limited to cancer cells alone. Chemotherapy drugs, designed to attack fast-growing cells, also affect healthy tissues, leading to various side effects. One of the most common adverse effects is peripheral neuropathy, a condition that affects the peripheral nerves and can manifest as tingling sensations, numbness, pain or weakness in the extremities.
Chemotherapy-induced peripheral neuropathy can be especially challenging for colon cancer patients, as it further aggravates quality of life during an already difficult period. Nerves responsible for motor and sensory function are compromised, affecting the patient's ability to perform daily activities and weakening their physical endurance. This phenomenon adds to the emotional and physical burden of fighting cancer.
However, there are tools that can positively influence these adverse effects, such as physical exercise. Although it may seem contradictory, regular physical exercise has been shown to have beneficial effects on peripheral neuropathy. Physical exercise can improve blood circulation and promote regeneration of damaged peripheral nerves. In addition, exercise helps to alleviate the pain and discomfort associated with neuropathy, thereby strengthening patients' functional capacity.
It is essential to emphasize that any exercise plan must be tailored to the individual capabilities of each patient, and medical supervision is essential. Therefore, the combination of chemotherapy and carefully planned physical exercise offers a comprehensive strategy to address both the disease and its side effects, providing colon cancer patients with a better quality of life during their journey to recovery.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •People diagnosed with colorectal cancer and who are receiving chemotherapy treatment.
- •Sedentary people who have not performed physical activity in the last 8 weeks.
- •Ability to understand the evaluation tests and the performance of the exercises.
- •Presence of XXX symptoms (If we focus on neuropathy, it should be inclusion criteria).
- •Voluntary participation in the study.
排除标准
- •Present contraindication/s for physical exercise (musculoskeletal diseases, severe cardiovascular disease, bone metastases,...).
结局指标
主要结局
Chemotherapy-induced neuropathy
时间窗: Baseline and immediately after the intervention
The EORTC CIPN20 questionnaire will be used.This questionnaire contains 20 items on which patients rate their experience for each symptom during the previous week using scores from 1 (not at all) to 4 (very much). The sum score was obtained by adding the scores of items 1 to 19 resulting in a sum score range of 19 to 76, which was termed CIPN20 sum1-19. Item 20 rates male impotence
次要结局
- Oxygen consumption(Before and after the intervention)
- Body Mass Index(Baseline and immediately after the intervention)
- Wellbeing(Baseline and immediately after the intervention)
- Anxiety and depression(Baseline and immediately after the intervention)
- Heighth(Baseline)
- Fatigue(Baseline and immediately after the intervention)
- Sleep quality(Baseline and immediately after the intervention)
- Sex(Baseline)
研究者
Juan Luis Sanchez Gonzalez
Principal Investigator. Dr. Juan Luis Sánchez González
University of Salamanca