A study to compare effectiveness of 2 different nerve blocks (Serratus posterior superior intercostal plane block and Pectoralis nerve block- PEC II) for pain relief in patients undergoing breast surgery.

Phase 4

Not yet recruiting

• Conditions: Malignant neoplasm of breast,

• Registration Number: CTRI/2025/06/088031
• Lead Sponsor: All India Institute of Medical Sciences, Patna

Brief Summary

Postoperative pain is asignificant concern following Modified Radical Mastectomy (MRM). Pain after MRMnot only causes a strong stress reaction and adverse emotionalexperience but also affects postoperative rehabilitation. Hence, differentanalgesia techniques, including local anaesthetic infiltration, intercostalnerve block, paravertebral block, Serratus anterior plane block and thoracicepidural anaesthesia, have been described to attenuate the intensity of acutepostoperative pain. Paraspinal block and thoracic epidural anaesthesia maycause parasympathetic symptoms, resulting in hypotension and bradycardia. Additionally, they could lead to general spinalanaesthesia, local hematoma, infection, anaesthetic poisoning, and paraspinalmuscle pain. Serratus anterior plane block only providesanterolateral hemi thoracic analgesia and Paravertebral block is associatedwith a high risk of complications such as pneumothorax and vascular injury. Serratusposterior superior intercostal plane block is a novel block that provideanteroposterior thoracic analgesia. Ultrasound guided Pectoral nerve block (PECII) has been the most popular block after breast surgeries because of its easeof administration and safety. Thisrandomized controlled trial aims to compare the analgesic efficacy of Serratusposterior superior block with Pectoral nerve block (PEC II).

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2025-05-28
• Study Start: 2025-06-18

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: Female
• Target Recruitment: 64

Inclusion Criteria

ASA 1 and 2 patients scheduled for Modified Radical Mastectomy.

Exclusion Criteria

1 Patient refusal to participate in the study 2 BMI more than 40 3 Skin lesions or infection at the planned site of needle insertion 4 Inability to understand about the PCA pump.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Requirement of post operative opiod (total dose of Morphine) in 24 hours.	24 hours.

Secondary Outcome Measures

Name	Time	Method
1 Intraoperative opioid (Fentanyl) consumption.	2 Time of first rescue analgesic administration.

Trial Locations

Locations (1)

All India Institute of Medical Sciences, Patna; 🇮🇳 Patna, BIHAR, India

All India Institute of Medical Sciences, Patna

🇮🇳Patna, BIHAR, India

Dr Ananda Geeta

Principal investigator

7010539415

18.anandageeta@gmail.com