A pilot study of a new technology for the investigation of high blood pressure in humans

Not Applicable

• Conditions: nderstanding the relationship between blood pressure and catecholamine rhythms in health and in secretory paraganglioma/phaeochromocytoma; Cancer

• Registration Number: ISRCTN64279315
• Lead Sponsor: niversity of Bristol

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2022-03-21
• Last Update Posted: 19 December 2023
• Study Completion: 2025-03-01

Recruitment & Eligibility

• Status: Ongoing
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

1. Males and females
2. Age >16 years
3. Clinical and radiological diagnosis of hormone-secreting phaeochromocytoma/paraganglioma
4. Healthy volunteers

Exclusion Criteria

1. Inability to attend study visits due to location
2. Positive urine drug screen (drugs of abuse – cocaine, methamphetamines etc) as these will alter catecholamine measurements
3. History of intravenous drug use - any
4. Current pregnancy, breast feeding

Patients:
5. Use of medication known to significantly interfere with measurement of metanephrines within 48 hours of or during the microdialysis sampling period

Healthy volunteers:
6. Any active medical condition
7. Any regular prescribed medication
8. Use of any prescribed, over-the-counter, herbal or other medication within or during the 48 hours of microdialysis sampling period, or, at the investigator’s discretion,
9. Significant hypertension at screening (SBP >160/DBP >100)
10. Night shift work or international travel (more than 2 time zones) within the previous 60 days
11. Regular intake of alcohol well in excess of recommended weekly consumption

Study & Design

• Study Type: Observational
• Study Design: Not specified