Prevalence and Outcome of Acute Hypoxemic Respiratory Failure in Wales
- Conditions
- Acute Respiratory Insufficiency
- Registration Number
- NCT03358043
- Lead Sponsor
- Dr. Negrin University Hospital
- Brief Summary
This study is aimed to establish the epidemiological chacacteristics and clinical outcomes of mechanically ventilated patients with acute hypoxemic respiratory failure admitted in a network of hospitals from Wales (U.K.).
- Detailed Description
The present study is aimed to establish the epidemiological characteristics and clinical outcomes of adult mechanically ventilated patients with acute hypoxemic respiratory failure \[defined as a PaO2/FiO2 ≤300 mmHg on positive end-expiratory pressure (PEEP) of 5 cmH2O or more and FiO2 of 0.3 or more\] admitted in a network of hospitals from Wales (U.K.). Although there are few previous published observational studies examining the incidence and mortality of patients with acute respiratory failure and ARDS, there are no studies specifically assessing the epidemiological characteristics, patterns of ventilation and clinical outcomes in patients with acute hypoxemic respiratory failure in the current era of lung protective ventilation. This study will be done simultaneously with the PANDORA (NCT03145974) in Spain.
The study is aimed to improve the knowledge on the epidemiology and outcome of ventilated patients, to identify the percentage of patients developing ARDS under the current definition, to validate a bedside scoring system for stratification of lung severity, and to examine the prognosis of hypoxemic respiratory failure, and risk factors associated with fatal outcome.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 1100
- Age ≥18-year old.
- Endotracheal intubation and mechanical ventilation, independent of whether the need for ventilatory support is shorter or longer than 24 hours. Only patients receiving invasive mechanical ventilation can be included, although patients could have been on non-invasive ventilation before intubation.
- PaO2/FiO2 ≤300 mmHg on invasive mechanical ventilation with a PEEP of 5 cmH2O or more, and with a FiO2 of 0.3 or more.
- No patients shhould be excluded (if they meet all the inclusion criteria), regardless of the underlying disease, estimated life expectancy, or duration of invasive mechanical ventilation.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Prevalence of hypoxemic acute respiratory failure 4 months The investigators will calculate the prevalence in relation to: (i) total number of ICU admissions; (ii) total number of mechanically ventilated patients during the study period; and (iii) per ICU bed available over the study period.
- Secondary Outcome Measures
Name Time Method Death in the hospital Hospital stay (maximum 6 months) outcome before discharge to home (overall and in each category of acute hypoxemic respiratory failure)
Trial Locations
- Locations (12)
Nevill Hall Hospital
🇬🇧Abergavenny, United Kingdom
Ysbyty Gwynedd
🇬🇧Bangor, United Kingdom
Cardiff University
🇬🇧Cardiff, United Kingdom
University Hospital of Wales
🇬🇧Cardiff, United Kingdom
Royal Glamorgan Hospital
🇬🇧Llantrisant, United Kingdom
Glangwili General Hospital
🇬🇧Carmarthen, United Kingdom
Withybush General Hospital
🇬🇧Haverfordwest, United Kingdom
Royal Gwent Hospital
🇬🇧Newport, United Kingdom
Prince Charles Hospital
🇬🇧Merthyr Tydfil, United Kingdom
Ysbyty Glan Clwyd
🇬🇧Rhyl, United Kingdom
Morriston Hospital
🇬🇧Swansea, United Kingdom
Wrexham Maelor Hospital
🇬🇧Wrexham, United Kingdom