NCT01165268已完成1 期
Characterization of the Kinetics of Renal Glucose Reabsorption in Response to Dapagliflozin in Healthy Subjects and in Subjects With Type 2 Diabetes Mellitus
适应症
干预措施
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 发起方
- AstraZeneca
- 入组人数
- 24
- 试验地点
- 1
- 主要终点
- The reduction in TmG after 7 days of oral administration of 10 mg of dapagliflozin
研究概览
简要总结
It is anticipated that 7 days of oral administration of 10 mg dapagliflozin will reduce the renal glucose reabsorption similarly in healthy subjects and in subjects with T2DM.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
研究组 & 干预措施
Dapagliflozin (T2DM)
Active Comparator
干预措施: Dapagliflozin (Drug)
Dapagliflozin (Healthy Subjects)
Active Comparator
干预措施: Dapagliflozin (Drug)
结局指标
主要结局
The reduction in TmG after 7 days of oral administration of 10 mg of dapagliflozin
时间窗: After 7 days of oral administration of 10 mg of dapagliflozin
次要结局
- Splay of the glucose titration curve(After 7 days of oral administration of 10 mg of dapagliflozin)
- Pharmacokinetics (Cmin, Cmax, Tmax, and AUC (TAU)) of dapagliflozin(Study Day 8)
研究者
研究点 (1)
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